Anti-PARP9 Antibody Picoband®

SKU: A08508-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Mouse, Rat
ELISA, 0.1-0.5μg/ml, -

Gene Name: PARP9

Specificity:

Background: Poly (ADP-ribosyl)ation is a post-translational modification of proteins mediated by one of the 17 members of the poly (ADP-ribose) polymerases (PARP). PARP-9 belongs to the subfamily of macroPARPs, associating one to three macro domains to the PARP domain. Overexpression of PARP-9 stimulates cell migration in vitro, suggesting a role for PARP-9 in the promotion of malignant B cell migration and dissemination in high risk DLBCL. PARP-9 is also likely a transcription coactivator, its overexpression in B lymphocytes, stimulated by IFNγ, inducing the transcription of IFNγ-controlled genes.

Immunogen: E.coli-derived human PARP9 recombinant protein (Position: R117-E824).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Aguiar, R. C. T., Takeyama, K., He, C., Kreinbrink, K., Shipp, M. A. B-aggressive lymphoma family proteins have unique domains that modulate transcription and exhibit poly(ADP-ribose) polymerase activity. J. Biol. Chem. 280: 33756-33765, 2005. 2. Aguiar, R. C. T., Yakushijin, Y., Kharbanda, S., Salgia, R., Fletcher, J. A., Shipp, M. A. BAL is a novel risk-related gene in diffuse large B-cell lymphomas that enhances cellular migration. Blood 96: 4328-4334, 2000. 3. Juszczynski, P., Kutok, J. L., Li, C., Mitra, J., Aguiar, R. C. T. BAL1 and BBAP are regulated by a gamma interferon-responsive biional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate. Molec. Cell. Biol. 26: 5348-5359, 2006.

Uniprot ID: Q8IXQ6

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 96 kDa

Calculated Molecular Weight:

Gene ID: 83666

Protein Name: Protein mono-ADP-ribosyltransferase PARP9

Gene Full Name: poly(ADP-ribose) polymerase family member 9

Synonyms: B aggressive lymphoma protein; BAL; BAL1; PARP 9; PARP9; Poly [ADP ribose] polymerase 9