Anti-NRXN2 Antibody Picoband®

SKU: A08915

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: WB

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat

Gene Name: NRXN2

Specificity:

Background: This gene encodes a member of the neurexin gene family. The products of these genes function as cell adhesion molecules and receptors in the vertebrate nervous system. These genes utilize two promoters. The majority of transcripts are produced from the upstream promoter and encode alpha-neurexin isoforms while a smaller number of transcripts are produced from the downstream promoter and encode beta-neuresin isoforms. The alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and have been shown to interact with neurexophilins. The beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. Alternative splicing and the use of alternative promoters may generate thousands of transcript variants (PMID: 12036300, PMID: 11944992).

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human NRXN2. Human NRXN2 shares 100% amino acid (aa) sequence identity with both mouse and rat NRXN2.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Bergman, L., Silins, G., Grimmond, S., Hummerich, H., Stewart, C., Little, P., Hayward, N. A 500-kb sequence-ready cosmid contig and transcript map of the MEN1 region on 11q13. Genomics 55: 49-56, 1999. 2. Gauthier, J., Siddiqui, T. J., Huashan, P., Yokomaku, D., Hamdan, F. F., Champagne, N., Lapointe, M., Spiegelman, D., Noreau, A., Lafreniere, R. G., Fathalli, F., Joober, R., and 9 others. Truncating mutations in NRXN2 and NRXN1 in autism spectrum disorders and schizophrenia. Hum. Genet. 130: 563-573, 2011. 3. Koh, A., Tao, S., Goh, Y. J., Chaganty, V., See, K., Purushothaman, K., Orban, L., Mathuru, A. S., Wohland, T., Winkler, C. A Neurexin2aa deficiency results in axon pathfinding defects and increased anxiety in zebrafish. Hum. Molec. Genet. 29: 3765-3780, 2021.

Uniprot ID: P58401

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 185 kDa

Calculated Molecular Weight: 185 kDa

Gene ID: 9379

Protein Name: Neurexin-2-beta

Gene Full Name: neurexin 2

Synonyms: NRXN2; Neurexin-2-beta; Neurexin II-beta