Anti-NR2F6 Antibody Picoband®

SKU: PB10081

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Rat

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Human, Rat

Gene Name: NR2F6

Specificity: No cross reactivity with other proteins.

Background: Nuclear receptor subfamily 2 group F member 6 is a protein that in humans is encoded by the NR2F6 gene. It is a member of the nuclear receptor family of intracellular transcription factors. It has been shown to function as a coregulator of other nuclear receptors. NR2F6 impairs the formation of mature red blood cells in animals that over-express NR2F6 in their bone marrow. Mice that over expression of NR2F6 in their bone marrow cells have a block at the pro-erythroblast stage of blood cell development both in the bone marrow and in the spleen of animals that have excessive expression of NR2F6. So, when inhibition of differentiation of stem cell is desired, inhibition of differentiation is achieved through induction of increased NR2F6 activity. In situations where differentiation of stem cells into a cell of increased maturity is desired, inhibition of NR2F6 activity must be performed.

Immunogen: E. coli-derived human NR2F6 recombinant protein (Position: M270-Q404). Human NR2F6 shares 99.3% amino acid (aa) sequence identity with both mouse and rat NR2F6.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg NaN3.
*This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Ichim, C.V. and Ichim, T., (2015). Modulation of Hematopoietic Stem Cell Differentiation. U.S. Patent 20,150,299,712. 2. Warnecke M, Oster H, Revelli JP, Alvarez-Bolado G, Eichele G (March 2005). Abnormal development of the locus coeruleus in Ear2(Nr2f6)-deficient mice impairs the functionality of the forebrain clock and affects nociception. Genes & Development 19 (5): 614–25.

Uniprot ID: P10588

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 43 kDa

Calculated Molecular Weight: 42979 MW

Gene ID: 2063

Protein Name: Nuclear receptor subfamily 2 group F member 6

Gene Full Name: nuclear receptor subfamily 2 group F member 6

Synonyms: EAR-2; EAR 2; EAR2; ERBAL2; NR2F6; V erbA related protein 2