Anti-NPTX2 Antibody Picoband®

SKU: A09667-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5 μg/ml, Mouse, Rat
ELISA, 0.1-0.5 μg/ml, -

Gene Name: NPTX2

Specificity:

Background: Neuronal pentraxin-2 is a protein that in humans is encoded by the NPTX2 gene. This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD.

Immunogen: E.coli-derived human NPTX2 recombinant protein (Position: G16-L431). Human NPTX2 shares 96.9% and 95.7% amino acid (aa) sequence identity with mouse and rat NPTX2, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Abernethy, T. J., Avery, O. T. The occurrence during acute infections of a protein not normally present in the blood. I. Distribution of the reactive protein in patients' sera and the effect of calcium on the flocculation reaction with C polysaccharide of pneumococcus. J. Exp. Med. 73: 173-182, 1941. 2. Hsu, Y.-C., Perin, M. S. Human neuronal pentraxin II (NPTX2): conservation, genomic structure, and chromosomal localization. Genomics 28: 220-227, 1995. 3. Schlimgen, A. K., Helms, J. A., Vogel, H., Perin, M. S. Neuronal pentraxin, a secreted protein with homology to acute phase proteins of the immune system. Neuron 14: 519-526, 1995.

Uniprot ID: P47972

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 47 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 4885

Protein Name: Neuronal pentraxin-2

Gene Full Name: neuronal pentraxin 2

Synonyms: NARP; Neuronal pentraxin 2; neuronal pentraxin II; NPTX2