Anti-MC4-R/MC4R Antibody Picoband®

SKU: A00619-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: Flow Cytometry,IF,IHC,ICC,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human
Immunocytochemistry/Immunofluorescence, 2μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human

Gene Name: MC4R

Specificity: No cross reactivity with other proteins.

Background: Melanocortin receptor 4 is a protein that in humans is encoded by the MC4R gene. This gene is mapped to 18q21.32. The protein encoded by this gene is a membrane-bound receptor and member of the melanocortin receptor family. The encoded protein interacts with adrenocorticotropic and MSH hormones and is mediated by G proteins. This is an intronless gene. Defects in this gene are a cause of autosomal dominant obesity.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human MC4-R/MC4R, which shares 88.5% and 80.8% amino acid (aa) sequence identity with mouse and rat MC4-R/MC4R, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Hardy, R., Wills, A. K., Wong, A., Elks, C. E., Wareham, N. J., Loos, R. J. F., Kuh, D., Ong, K. K. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum. Molec. Genet. 19: 545-552, 2010. 2. Hebebrand, J., Geller, F., Dempfle, A., Heinzel-Gutenbrunner, M., Raab, M., Gerber, G., Wermter, A.-K., Horro, F. F., Blundell, J., Schafer, H., Remschmidt, H., Herpertz, S., Hinney, A. Binge-eating episodes are not characteristic of carriers of melanocortin-4 receptor gene mutations. Molec. Psychiat. 9: 796-800, 2004. 3. Heid, I. M., Vollmert, C., Hinney, A., Doring, A., Geller, F., Lowel, H., Wichmann, H.-E., Illig, T., Hebebrand, J., Kronenberg, F., the KORA group. Association of the 1031 MC4R allele with decreased body mass in 7937 participants of two population based surveys. J. Med. Genet. 42: e21, 2005. Note: Electronic Article.

Uniprot ID: P32245

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 37 kDa

Calculated Molecular Weight: 57371 MW

Gene ID: 4160

Protein Name: Lithostathine-1-alpha/beta

Gene Full Name: melanocortin 4 receptor

Synonyms: melanocortin 4 receptor; BMIQ20; MC4R