Anti-LHPP Antibody Picoband®

SKU: A10687

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,ICC,IF,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Immunocytochemistry/Immunofluorescence, 5 μg/ml, Human
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: LHPP

Specificity:

Background: LHPP, also known as HDHD2B, is a 270 amino acid protein that exists as a homodimer and is a member of the HAD-like hydrolase superfamily. Expressed in liver, kidney and moderately in brain, LHPP is encoded by a gene located on 10, which houses over 1,200 genes and comprises nearly 4.5 % of the human genome. Defects in some of the genes that map to chromosome 10 are associated with Charcot-Marie Tooth disease, Jackson-Weiss syndrome, Usher syndrome, nonsyndromatic deafness, Wolman?s syndrome, Cowden syndrome, multiple endocrine neoplasia type 2 and porphyria

Immunogen: E.coli-derived human LHPP recombinant protein (Position: K6-K270).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Hindupur, S. K., Colombi, M., Fuhs, S. R., Matter, M. S., Guri, Y., Adam, K., Cornu, M., Piscuoglio, S., Ng, C. K. Y., Betz, C., Liko, D., Quagliata, L., Moes, S., Jenoe, P., Terracciano, L. M., Heim, M. H., Hunter, T., Hall, M. N. The protein histidine phosphatase LHPP is a tumour suppressor. Nature 555: 678-682, 2018. 2. Neff, C. D., Packer, J. C. L., Chen, Y., Potter, J., Riley, R., Davenport, C., DeGrado Warren, J., Jammulapati, S., Bhathena, A., Choi, W. S., Kroeger, P. E., Metzger, R. E., Gutin, A., Skolnick, M. H., Shattuck, D., Katz, D. A. Evidence for HTR1A and LHPP as interacting genetic risk factors in major depression. Molec. Psychiat. 14: 621-630, 2009. 3. Yokoi, F., Hiraishi, H., Izuhara, K. Molecular cloning of a cDNA for the human phospholysine phosphohistidine inorganic pyrophosphate phosphatase. J. Biochem. 133: 607-614, 2003.

Uniprot ID: Q9H008

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross reactivity with other proteins.

Isotype: IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 29 kDa

Calculated Molecular Weight: 52588 MW

Gene ID: 64077

Protein Name: Phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Gene Full Name: phospholysine phosphohistidine inorganic pyrophosphate phosphatase

Synonyms: hLHPP; LHPP