Anti-Kir6.1/KCNJ8 Antibody Picoband®

SKU: A04950-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: KCNJ8

Specificity:

Background: Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein. Potassium channels are present in most mammalian cells, where they participate in a wide range of physiologic responses. The protein encoded by this gene is an integral membrane protein and inward-rectifier type potassium channel. The encoded protein, which has a greater tendency to allow potassium to flow into a cell rather than out of a cell, is controlled by G-proteins. Defects in this gene may be a cause of J-wave syndromes and sudden infant death syndrome (SIDS).

Immunogen: E.coli-derived human Kir6.1/KCNJ8 recombinant protein (Position: M1-S424).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl and 0.2mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500μg/ml.

Reference: 1. Barajas-Martinez, H., Hu, D., Ferrer, T., Onetti, C. G., Wu, Y., Burashnikov, E., Boyle, M., Surman, T., Urrutia, J., Veltmann, C., Schimpf, R., Borggrefe, M., Wolpert, C., Ibrahim, B. B., Sanchez-Chapula, J. A., Winters, S., Haissaguerre, M., Antzelevitch, C. Molecular genetic and functional association of Brugada and early repolarization syndromes with S422L missense mutation in KCNJ8. Heart Rhythm 9: 548-555, 2012. 2. Beltrame, J. F., Sasayama, S., Maseri, A. Racial heterogeneity in coronary artery vasomotor reactivity: differences between Japanese and Caucasian patients. J. Am. Coll. Cardiol. 33: 1442-1452, 1999. 3. Brownstein, C. A., Towne, M. C., Luquette, L. J., Harris, D. J., Marinakis, N. S., Meinecke, P., Kutsche, K., Campeau, P. M., Yu, T. W., Margulies, D. M., Agrawal, P. B., Beggs, A. H. Mutation of KCNJ8 in a patient with Cantu syndrome with unique vascular abnormalities: support for the role of K(ATP) channels in this condition. Europ. J. Med. Genet. 56: 678-682, 2013.

Uniprot ID: Q15842

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 48 kDa

Calculated Molecular Weight: 45468 MW

Gene ID: 3764

Protein Name: ATP-sensitive inward rectifier potassium channel 8

Gene Full Name: potassium inwardly rectifying channel subfamily J member 8

Synonyms: KCNJ8; Kir6.1; uKATP 1