Anti-Insulin Ins2 Antibody (Monoclonal, K36AC10)

SKU: MA1052

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Rabbit,Rat

Applications: IHC

Application Details: Immunohistochemistry (Paraffin-embedded Section), 0.4-1μg/ml, Human, rabbit, rat

Gene Name: INS

Specificity: No cross reactivity with other proteins.

Background: Insulin, synthesized by the beta cells of the islets of Langerhans, consists of 2 dissimilar polypeptide chains, A and B, which are linked by 2 disulfide bonds. The insulin gene contains 3 exons and 2 introns; exon 2 encodes the signal peptide, the B chain, and part of the C peptide, while exon 3 encodes the remainder of the C peptide and the A chain. Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Harper et al. (1981) and Harper and Saunders (1981) assigned the insulin gene to 11p15.5 by in situ hybridization.

Immunogen: Human insulin.

Clonality: Monoclonal

Contents: Mouse IgG in stabilizing components, 1.2% sodium acetate and 0.01mg NaN3. *This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Ascites

Reconstitution: Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Reference: 1. Harper, M. E.; Ullrich, A.; Saunders, G. F. : Localization of the human insulin gene to the distal end of the short arm of chromosome 11. Proc. Nat. Acad. Sci. 78: 4458-4460, 1981. 2. Owerbach, D.; Bell, G. I.; Rutter, W. J.; Shows, T. B. : The insulin gene is located on chromosome 11 in human. Nature 286: 82-84, 1980. 3. Huerre, C.; Gilgenkrantz, S.; Leonard, C.; Pictet, R.; Kaplan, J. C.; Junien, C. : Regional assignment of the structural gene for insulin to 11p15.1-11p15.5 by deletion mapping. (Abstract) Cytogenet. Cell Genet. 37: 495, 1984.

Uniprot ID: P01323

Host: Mouse

Concentration: Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Mouse IgG1

Phospho_site:

Clone Number: Clone: K36AC10

Observed Molecular Weight: 70 kDa

Calculated Molecular Weight: 12339 MW

Gene ID: Human(3630), Mouse(16334), Rat(24509)

Protein Name: Insulin-2 [Cleaved into: Insulin-2 B chain; Insulin-2 A chain]

Gene Full Name: insulin 2

Synonyms: PROINSULIN; ILPR; IRDN; IDDM2; MODY10; Insulin2; Ins-2