Anti-IL17A Antibody

SKU: A00421-4

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human

Applications: IHC

Application Details: Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml/ml, Human

Gene Name: IL17A

Specificity:

Background: Interleukin-17A is a protein that in humans is encoded by the IL17A gene. This gene is a member of the IL-17 receptor family which includes five members (IL-17RA-E) and the encoded protein is a proinflammatory cytokine produced by activated T cells. IL-17A-mediated downstream pathways induce the production of inflammatory molecules, chemokines, antimicrobial peptides, and remodeling proteins. The encoded protein elicits crucial impacts on host defense, cell trafficking, immune modulation, and tissue repair, with a key role in the induction of innate immune defenses. This cytokine stimulates non-hematopoietic cells and promotes chemokine production thereby attracting myeloid cells to inflammatory sites. This cytokine also regulates the activities of NF-kappaB and mitogen-activated protein kinases and can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). IL-17A plays a pivotal role in various infectious diseases, inflammatory and autoimmune disorders, and cancer. High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The lung damage induced by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is to a large extent, a result of the inflammatory response promoted by cytokines such as IL17A

Immunogen: A synthetic peptide corresponding to a sequence in the middle region of human IL17A, which shares 88.2% amino acid (aa) sequence identity with mouse and rat IL17A.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Allen, C. E., McClain, K. L. Interleukin-17A is not expressed by CD207+ cells in Langerhans cell histiocytosis lesions. (Letter) Nature Med. 15: 483-484, 2009. 2. Amadi-Obi, A., Yu, C.-R., Liu, X., Mahdi, R. M., Clarke, G. L., Nussenblatt, R. B., Gery, I., Lee, Y. S., Egwuagu, C. E. TH17 cells contribute to uveitis and scleritis and are expanded by IL-2 and inhibited by IL-27/STAT1. Nature Med. 13: 711-718, 2007. 3. Arico, M., Henter, J.-I., Egeler, R. M., Delprat, C. Reply to Allen and McClain. (Letter) Nature Med. 15: 484-485, 2009.

Uniprot ID: Q16552

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 27 kDa

Calculated Molecular Weight:

Gene ID: 3605

Protein Name: Growth and differentiation factor 9

Gene Full Name: interleukin 17A

Synonyms: CTLA 8; CTLA8; IL 17; IL 17A; IL17; IL-17; IL17A; interleukin 17A