Anti-Glucagon/GCG Antibody

SKU: PB9705

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: IF,IHC

Application Details: Immunohistochemistry (Paraffin-embedded Section), 0.5-1μg/ml, Human, Mouse, Rat
Immunofluorescence, 2μg/ml, Rat

Gene Name: GCG

Specificity: No cross reactivity with other proteins.

Background: The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.

Immunogen: A synthetic peptide corresponding to a sequence at the N-terminus of human Glucagon/GCG, identical to the related mouse and rat sequences.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Arora S, Galich P (Mar 2009). Myth: glucagon is an effective first-line therapy for esophageal foreign body impaction. Cjem 11 (2): 169–71. 2. Holz, G. G., IV, Kuhtreiber, W. M., Habener, J. F. Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1 (7-37). Nature 361: 362-365, 1993. 3. Liljenquist JE, Bomboy JD, Lewis SB, Sinclair-Smith BC, Felts PW, Lacy WW, Crofford OB, Liddle GW (Jan 1974). Effects of glucagon on lipolysis and ketogenesis in normal and diabetic men (PDF). The Journal of Clinical Investigation 53 (1): 190–7.

Uniprot ID: P01275

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 10 kDa

Calculated Molecular Weight: 20909 MW

Gene ID: 2641

Protein Name: Pro-glucagon [Cleaved into: Glicentin; Glicentin-related polypeptide

Gene Full Name: glucagon

Synonyms: GCG; GLP 2; GLP1; GLP2; glucagon; GRPP; GRPP Oxyntomodulin; OXM; Proglucagon