Anti-GJC2 Antibody Picoband®

SKU: PB9706

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Human, Mouse, Rat

Gene Name: GJC2

Specificity: No cross reactivity with other proteins.

Background: Gap junction gamma-2 (GJC2), also known as connexin-46.6 (Cx46.6) and connexin-47 (Cx47) and gap junction alpha-12 (GJA12), is a protein that in humans is encoded by the GJC2 gene. It is mapped to 1q42.13. This gene encodes a gap junction protein. Gap junction proteins are members of a large family of homologous connexins and comprise 4 transmembrane, 2 extracellular, and 3 cytoplasmic domains. This gene plays a key role in central myelination and is involved in peripheral myelination in humans.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human GJC2, different from the related mouse and rat sequences by five amino acids.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg NaN3.
*This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Ferrell RE, Baty CJ, Kimak MA; et al. (2010). GJC2 missense mutations cause human lymphedema.. Am. J. Hum. Genet. 86 (6): 943–8. 2. Ostergaard P, Simpson MA, Brice G; et al. (2011). Rapid identification of mutations in GJC2 in primary lymphoedema using whole exome sequencing combined with linkage analysis with delineation of the phenotype.. J. Med. Genet. 48 (4): 251–5. 3. Wolf NI, Cundall M, Rutland P; et al. (2007). Frameshift mutation in GJA12 leading to nystagmus, spastic ataxia and CNS dys-/demyelination..Neurogenetics 8 (1): 39–44.

Uniprot ID: Q5T442

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 47 kDa

Calculated Molecular Weight: 47002 MW

Gene ID: 57165

Protein Name: Gap junction gamma-2 protein

Gene Full Name: gap junction protein gamma 2

Synonyms: Connexin 46.6; Connexin 47; CX46.6; Cx47; Gap junction alpha 12 protein; Gap junction gamma 2 protein; GJA12; GJC2; HLD2; PMLDAR; SPG44