Anti-GABA A Receptor gamma 2/GABRG2 Antibody Picoband®

SKU: A02361-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: WB,IHC,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5μg/ml, Rat
Immunohistochemistry (Paraffin-embedded Section), 2-5μg/ml, Human, Mouse
Flow Cytometry (Fixed), 1-3μg/1x10⁶ cells, Human
ELISA, 0.1-0.5μg/ml, -

Gene Name: GABRG2

Specificity:

Background: Gamma-aminobutyric acid receptor subunit gamma-2 is a protein that in humans is encoded by the GABRG2 gene. This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammlian brain, where it acts at GABA-A receptors, which are ligand-gated chloride channels. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene have been associated with epilepsy and febrile seizures. Multiple transcript variants encoding different isoforms have been identified for this gene.

Immunogen: E.coli-derived human GABA A Receptor gamma 2/GABRG2 recombinant protein (Position: Q40-R446).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.01mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Audenaert, D., Schwartz, E., Claeys, K. G., Claes, L., Deprez, L., Suls, A., Van Dyck, T., Lagae, L., Van Broeckhoven, C., Macdonald, R. L., De Jonghe, P. A novel GABRG2 mutation associated with febrile seizures. Neurology 67: 687-690, 2006. 2. Baulac, S., Huberfeld, G., Gourfinkel-An, I., Mitropoulou, G., Beranger, A., Prud'homme, J.-F., Baulac, M., Brice, A., Bruzzone, R., LeGuern, E. First genetic evidence of GABA(A) receptor dysfunction in epilepsy: a mutation in the gamma-2-subunit gene. Nature Genet. 28: 46-48, 2001. 3. Buckwalter, M. S., Lossie, A. C., Scarlett, L. M., Camper, S. A. Localization of the human chromosome 5q genes Gabra-1, Gabrg-2, I1-4, I1-5, and Irf-1 on mouse chromosome 11. Mammalian Genome 3: 604-607, 1992.

Uniprot ID: P18507

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50 kDa

Calculated Molecular Weight: 53054 MW

Gene ID: 2566

Protein Name: Gamma-aminobutyric acid receptor subunit gamma-2

Gene Full Name: gamma-aminobutyric acid type A receptor subunit gamma2

Synonyms: CAE2; ECA2; GABA A receptor gamma 2; GABAA receptor gamma 2; GABRG2; GEFSP3