Anti-ERV31/ERV3-1 Antibody Picoband®

SKU: RP1091

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human

Applications: WB

Application Details: Western blot, 0.1-0.5μg/ml, Human

Gene Name: ERV3-1

Specificity: No cross reactivity with other proteins.

Background: HERV-R_7q21.2 provirus ancestral Env polyprotein, also known as ERV3-1, is a protein that in humans is encoded by the ERV3 gene. By radiation hybrid analysis, the ERV3 gene is mapped to chromosome 7q11.2. The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human ERV31.

Clonality: Polyclonal

Contents: Each vial contains antibody formulated with stabilizing components, 0.9 mg NaCl, 0.2 mg Na2HPO4, and 0.05 mg NaN3.
*This antibody is supplied in a stabilized formulation.
Compatibility with conjugation reactions depends on the chemistry of the conjugation method used.
For conjugation methods that are not compatible with the stabilizing components present in this formulation, a carrier-free antibody format is required.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Kato, N., Shimotohno, K., Van Leeuwen, D., Cohen, M. Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Kruppel. Molec. Cell. Biol. 10: 4401-4405, 1990. 2. Kim, H.-S., Crow, T. J., Hyun, B.-H. Assignment of the endogenous retrovirus HERV-R (ERV3) to human chromosome 7q11.2 by radiation hybrid mapping. Cytogenet. Cell Genet. 89: 10 only, 2000. 3. O'Connell C, O'Brien S, Nash WG, Cohen M (Dec 1984). ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships. Virology 138 (2): 225–35.

Uniprot ID: Q14264

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 68 kDa

Calculated Molecular Weight: 67942 MW

Gene ID: 2086

Protein Name: Endogenous retrovirus group 3 member 1 Env polyprotein

Gene Full Name: endogenous retrovirus group 3 member 1, envelope

Synonyms: Endogenous retrovirus group 3 member 1; envelope; ERV-R; ERV3; ERVR; HERV-R; HERVR; envR; ERV3-1