Anti-Dexras1/RASD1 Antibody Picoband®

SKU: A05991-1

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,Flow Cytometry,WB

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse, Rat
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: RASD1

Specificity:

Background: Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein that in humans is encoded by the RASD1 gene on chromosome 17. This gene encodes a member of the Ras superfamily of small GTPases and is induced by dexamethasone. The encoded protein is an activator of G-protein signaling and acts as a nucleotide exchange factor for Gi-Go proteins. This protein interacts with the neuronal nitric oxide adaptor protein CAPON, and a nuclear adaptor protein FE65, which interacts with the Alzheimer's disease amyloid precursor protein. This gene may play a role in dexamethasone-induced alterations in cell morphology, growth and cell-extracellular matrix interactions. Epigenetic inactivation of this gene is closely correlated with resistance to dexamethasone in multiple myeloma cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Immunogen: E.coli-derived human Dexras1/RASD1 recombinant protein (Position: M1-S281).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Cheng, H.-Y. M., Obrietan, K., Cain, S. W., Lee, B. Y., Agostino, P. V., Joza, N. A., Harrington, M. E., Ralph, M. R., Penninger, J. M. Dexras1 potentiates photic and suppresses nonphotic responses of the circadian clock. Neuron 43: 715-728, 2004. 2. Fang, M., Jaffrey, S. R., Sawa, A., Ye, K., Luo, X., Snyder, S. H. Dexras1: a G protein specifically coupled to neuronal nitric oxide synthase via CAPON. Neuron 28: 183-193, 2000. 3. Gross, M. B. Personal Communication. Baltimore, Md. 10/30/2017.

Uniprot ID: Q9Y272

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 32 kDa

Calculated Molecular Weight: 80420 MW

Gene ID: 51655

Protein Name: Dexamethasone-induced Ras-related protein 1

Gene Full Name: ras related dexamethasone induced 1

Synonyms: RASD1; AGS1; DEXRAS1; Dexamethasone-induced Ras-related protein 1; Activator of G-protein signaling 1