Anti-CD137/Tnfrsf9 Antibody Picoband®

SKU: A00867-2

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Mouse,Rat

Applications: ELISA (Cap),WB

Application Details: Western blot, 0.1-0.5μg/ml
ELISA (Cap), 1-5μg/ml

Gene Name: Tnfrsf9

Specificity: No cross reactivity with other proteins.

Background: CD137 is a member of the tumor necrosis factor (TNF) receptor family. This receptor contributes to the clonal expansion, survival, and development of T cells. It can also induce proliferation in peripheral monocytes, enhance T cell apoptosis induced by TCR/CD3 triggered activation, and regulate CD28 co-stimulation to promote Th1 cell responses. The expression of this receptor is induced by lymphocyte activation. TRAF adaptor proteins have been shown to bind to this receptor and transduce the signals leading to activation of NF-kappaB.

Immunogen: E. coli-derived mouse CD137 recombinant protein (Position: V24-L187).

Clonality: Polyclonal

Contents: Each vial contains 4mg Trehalose, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. McNamara, J. O., II, Kolonias, D., Pastor, F., Mittler, R. S., Chen, L., Giangrande, P. H., Sullenger, B., Gilboa, E. Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice. J. Clin. Invest. 118: 376-386, 2008. 2. Munks, M. W., Mourich, D. V., Mittler, R. S., Weinberg, A. D., Hill, A. B. 4-1BB and OX40 stimulation enhance CD8 and CD4 T-cell responses to a DNA prime, poxvirus boost vaccine.Immunology 112: 559-566, 2004. 3. Seo, S. K., Choi, J. H., Kim, Y. H., Kang, W. J., Park, H. Y., Suh, J. H., Choi, B. K., Vinay, D. S., Kwon, B. S. 4-1BB-mediated immunotherapy of rheumatoid arthritis. Nature Med. 10: 1088-1094, 2004. Note: Erratum: Nature Med. 10: 1261 only, 2004.

Uniprot ID: P20334

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate: This is the unconjugated antibody. It is also available with 10 conjugation options, including Biotin, Cy3, Fluoro488, Fluoro550, Fluoro594, FITC, HRP, APC, PE, and Fluoro647. A carrier-free (BSA-free) version is also available. Additional charges may apply for some options. Please contact us for a quote

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 65 kDa

Calculated Molecular Weight:

Gene ID: 21942

Protein Name: Tumor necrosis factor receptor superfamily member 9

Gene Full Name: tumor necrosis factor receptor superfamily, member 9

Synonyms: 4 1BB; 4 1BB ligand receptor; CD137; CDw137; ILA; T cell antigen 4 1BB homolog; T cell antigen ILA; TNFRSF9