Anti-C19orf2/URI1 Antibody Picoband®

SKU: A05245-2

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: URI1

Specificity:

Background: Unconventional prefoldin RPB5 interactor, also called URI1, is a protein that in humans is encoded by the URI1 gene. This gene encodes member of the prefoldin family of molecular chaperones. The encoded protein functions as a scaffolding protein and plays roles in ubiquitination and transcription, in part though interactions with the RNA polymerase II subunit RPB5. This gene may play a role in multiple malignancies including ovarian cancer and hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 22.

Immunogen: E.coli-derived human C19orf2/URI1 recombinant protein (Position: K89-Q532).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Chaves-Perez, A., Yilmaz, M., Perna, C., de la Rosa, S., Djouder, N. URI is required to maintain intestinal architecture during ionizing radiation. Science 364: eaaq1165, 2019. Note: Electronic Article. 2. Dorjsuren, D., Lin, Y., Wei, W., Yamashita, T., Nomura, T., Hayashi, N., Murakami, S. RMP, a novel RNA polymerase II subunit 5-interacting protein, counteracts transactivation by hepatitis B virus X protein. Molec. Cell Biol. 18: 7546-7555, 1998. 3. Gstaiger, M., Luke, B., Hess, D., Oakeley, E. J., Wirbelauer, C., Blondel, M., Vigneron, M., Peter, M., Krek, W. Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. Science 302: 1208-1212, 2003.

Uniprot ID: O94763

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 80 kDa

Calculated Molecular Weight: 39411 MW

Gene ID: 8725

Protein Name: Unconventional prefoldin RPB5 interactor 1

Gene Full Name: URI1 prefoldin like chaperone

Synonyms: C19orf2; NNX3; PPP1R19; Protein NNX3; RMP; RPB5 mediating protein; URI