Anti-c-Fos/FOS Antibody Picoband®

SKU: A00297-1

Size: 100 μg

Storage: Store at -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freeze-thaw cycles.

Form: Lyophilized

Reactivity: Human,Mouse,Rat

Applications: ELISA,WB

Application Details: Western blot, 0.25-0.5μg/ml, Human, Mouse, Rat
ELISA, 0.1-0.5μg/ml, -

Gene Name: FOS

Specificity:

Background: The human oncogene c-fos is cellular homolog of the transforming gene of Finkel-Biskis-Jinkins (FBJ) murine osteosarcoma virus which was mapped to a single human chromosome. c-Fos is encoded by the FOS gene. FOS was the first transcription factor identified that has a critical function in regulating the development of cells destined to form and maintain the skeleton. FOS is also a major component of the activator protein-1 (AP-1) transcription factor complex, which includes members of the JUN family. c-fos is a major nuclear target for signal transduction pathways involved in the regulation of cell growth, differentiation, and transformation. Using transgenic and knockout mice, Grigoriadis et al. (1995) established a unique role for the proto-oncogene and nuclear transcription factor, Fos, in regulating the differentiation and activity of specific bone cell populations, both during normal development and in bone disease.

Immunogen: E.coli-derived human c-Fos/FOS recombinant protein (Position: N45-D293).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl and 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

Reference: 1. Barker, P. E.; Rabin, M.; Watson, M.; Breg, W. R.; Ruddle, F. H.; Verma, I. M. : Human c-fos oncogene mapped within chromosomal region 14q21-q31. Proc. Nat. Acad. Sci. 81: 5826-5830, 1984. 2. Saez, E.; Rutberg, S. E.; Mueller, E.; Oppenheim, H.; Smoluk, J.; Yuspa, S. H.; Spiegelman, B. M. : c-fos is required for malignant progression of skin tumors. Cell 82: 721-732, 1995. 3. Grigoriadis, A. E.; Wang, Z.-Q.; Wagner, E. F. : Fos and bone cell development: lessons from a nuclear oncogene. Trends Genet. 11: :436-441, 1995.

Uniprot ID: P01100

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 50-55 kDa

Calculated Molecular Weight: 41 kDa

Gene ID: 2353

Protein Name: Protein c-Fos

Gene Full Name: Fos proto-oncogene, AP-1 transcription factor subunit

Synonyms: AP 1; C FOS; Cellular oncogene fos; c-Fos; FOS; G0S7; Proto oncogene c Fos