Anti-Btc Antibody Picoband®

SKU: A02171-4

Size: 100 μg

Storage: At -20℃ for one year from date of receipt. After reconstitution, at 4℃ for one month. It can also be aliquotted and stored frozen at -20℃ for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Mouse

Applications: WB,IHC,ELISA

Application Details: Western blot, 0.5-1 μg/ml, Mouse
Immunohistochemistry(Paraffin-embedded Section), 2-5 μg/ml, Mouse
ELISA, 0.1-0.5 μg/ml, -

Gene Name: Btc

Specificity:

Background: Betacellulin is a protein that in humans is encoded by the BTC gene located on chromosome 4 at locus 4q13-q21. This gene encodes a member of the epidermal growth factor (EGF) family of proteins. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the secreted growth factor. A secreted form and a membrane-anchored form of this protein bind to multiple different EGF receptors. This protein promotes pancreatic cell proliferation and insulin secretion, as well as retinal vascular permeability. Mutations in this gene may be associated with type 2 diabetes in human patients.

Immunogen: E.coli-derived mouse Btc recombinant protein (Position: D32-Y111).

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Elbein SC, Wang X, Karim MA, et al. (2006). Analysis of coding variants in the betacellulin gene in type 2 diabetes and insulin secretion in African American subjects.. BMC Med. Genet. 7: 62. 2. Kim HS, Shin HS, Kwak HJ, Cho CH, Lee CO, Koh GY (February 2003). Betacellulin induces angiogenesis through activation of mitogen-activated protein kinase and phosphatidylinositol 3'-kinase in endothelial cell. FASEB J. 17 (2): 318–20.

Uniprot ID: Q05928

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins.

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 26 kDa

Calculated Molecular Weight: 63692 MW

Gene ID: 12223

Protein Name: Probetacellulin [Cleaved into: Betacellulin

Gene Full Name: betacellulin, epidermal growth factor family member

Synonyms: betacellulin; BTC; Probetacellulin