Anti-ARHGEF6 Antibody Picoband®

SKU: A05317-1

Size: 100 μg

Storage: At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

Form: Lyophilized

Reactivity: Human,Mouse

Applications: WB,Flow Cytometry,ELISA

Application Details: Western blot, 0.25-0.5 μg/ml, Human, Mouse
Flow Cytometry (Fixed), 1-3 μg/1x10⁶ cells, Human
ELISA, 0.1-0.5 μg/ml, -

Gene Name: ARHGEF6

Specificity:

Background: Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene. Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein is activated by PI3-kinase. Mutations in this gene can cause X-chromosomal non-specific cognitive disability.

Immunogen: E.coli-derived human ARHGEF6 recombinant protein (Position: E54-R765). Human ARHGEF6 shares 91.2% and 91.3% amino acid (aa) sequence identity with mouse and rat ARHGEF6, respectively.

Clonality: Polyclonal

Contents: Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.

Purification: Immunogen affinity purified.

Reconstitution: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Reference: 1. Gallo, G., Letourneau, P. C. Axon guidance: GTPases help axons reach their targets. Curr. Biol. 8: R80-R82, 1998. 2. Gedeon, A. K., Glass, I. A., Connor, J. M., Mulley, J. C. Genetic localisation of MRX27 to Xq24-26 defines another discrete gene for non-specific X-linked mental retardation. Am. J. Med. Genet. 64: 121-124, 1996. 3. Hamosh, A. Personal Communication. Baltimore, Md. 11/21/2018.

Uniprot ID: Q15052

Host: Rabbit

Concentration: Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Conjugate:

Cross Reactivity: No cross-reactivity with other proteins

Isotype: Rabbit IgG

Phospho_site:

Clone Number:

Observed Molecular Weight: 87 kDa

Calculated Molecular Weight: 87 kDa

Gene ID: 9459

Protein Name: Rho guanine nucleotide exchange factor 6

Gene Full Name: Rac/Cdc42 guanine nucleotide exchange factor 6

Synonyms: ARHGEF6; COOL2; KIAA0006; PIXA; MRX46; Cool-2; alphaPIX; alpha-PIX