AMACR/p504S antibody , Cat. # FNab00355

SKU: FNab00355

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:AMACR(Alpha-methylacyl-CoA racemase) belongs to the CaiB/BaiF CoA-transferase family. It is a mitochondrial and peroxisomal enzyme that catalyzes the conversion of 2R stereoisomers of phytanic and pristanic acid to their S counterparts. AMACR has previously been shown to be a highly sensitive marker for colorectal and clinically localized prostate cancer(PCa). However, AMACR expression is down-regulated at the transcript and protein level in hormone-refractory metastatic PCa, suggesting a hormone-dependent expression of AMACR(PMID:12213712). It has 3 isoforms produced by alternative splicing ang it can form a a dimer of 70-75 kDa(PMID:21812041). Defects in AMACR are the cause of alpha-methylacyl-CoA racemase deficiency(AMACRD) and congenital bile acid synthesis defect type 4(CBAS4).

Immunogen:alpha-methylacyl-CoA racemase

Synonyms:2 methylacyl CoA racemase, alpha methylacyl CoA racemase, AMACR, CBAS4, p504S, RACE

Observed MW:42 kDa

Uniprot ID:Q9UHK6

Reactivity:Human, rat

Tested Application:ELISA, IHC, WB

Recommended dilution:WB: 1:500-1:5000; IHC: 1:20-1:200

Gene ID:

Research Area:Stem Cells, Immunology, Metabolism, Cancer