AIF Polyclonal Antibody

SKU: E-AB-90029

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:AIF

Target Synonym:AIF;CMT2D;CMTX4;COWCK;COXPD6;DFNX5;NADMR;NAMSD;PDCD8;AIFM1

Research Areas:Cancer;Cell Biology;Epigenetics and Nuclear Signaling;Metabolism

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse;Rat

Application:WB;IHC;IF

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:O95831

Accession:

Background:This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells, and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition, this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6), a severe mitochondrial encephalomyopathy, as well as Cowchock syndrome, also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4), a disorder resulting in neuropathy, and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.

Concentration:1mg/mL

Immunogen:Recombinant fusion protein of human AIF

Buffer:PBS with 0.02% sodium azide,50% glycerol,pH7.3.

Purification method:Affinity purification

Dilution:WB 1:500-1:1000;IHC 1:50-1:200;IF 1:20-1:50

Calculated MW:26kDa/28kDa/35kDa/66kDa

ObservedMW:60kDa