Adenosine Deaminase Monoclonal Antibody

SKU: AN200057P

Size::

Storage:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Shipping:Ice bag

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Monoclonal Antibodies

Abbreviation:ADA

Target Synonym:ADA;adenosine deaminase;adenine deaminase;Adenosine Aminhydrolase;EC 3.5.4.4;ADA1;Adenosine aminohydrolase

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Metabolism

Conjugation:Unconjugated

Host:Mouse

Species reactivity:Human

Application:WB;IP

Isotype:IgG1

Clonality:Monoclonal

Clone NO.:9D6

UNIProt ID:P00813

Accession:

Background:Adenosine Deaminase (ADA, adenosine aminohydrolase) is one of the key enzymes of purine nucleotide catabolism. It catalyses the hydrolytic deamination of adenosine and deoxy‑adenosine to inosine and deoxyinosine . ADA is expressed in virtually all tissues and is expressed at high levels in T-lymphocytes. Adenosine Deaminase deficiency can cause a form of SCID (severe combined immunodeficiency) and lymphopenia in both B- and T-cell lineages . ADA can be used as a sensitive diagnostic marker for tuberculous pleuritis . Although it is primarily a cytosolic enzyme, ADA is known to be a positive regulator of T-cell co‑activation due to its binding to CD26 at the cell surface. The interaction of ADA with CD26 regulates lymphocyte-epithelial cell adhesion

Concentration:1 mg/mL

Immunogen:Recombinant Human Adenosine Deaminase Protein

Buffer:0.2 μm filtered solution in PBS

Purification method:Protein A

Dilution:WB 1:500-1:2000;IP 1-5μL/mg of lysate

Calculated MW:41 kDa

ObservedMW:41 kDa