See Below for Detailed Description
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Updated Date: Stock Protein updated on 20171228
Research areas: Signal Transduction
Target / Protein: TCN1
Biologically active: Not Tested
Expression system: E.coli
Species of origin: Homo sapiens (Human)
Delivery time: 3-7 business days
Uniprot ID: P20061
AA Sequence: EICEVSEENYIRLKPLLNTMIQSNYNRGTSAVNVVLSLKLVGIQIQTLMQKMIQQIKYNVKSRLSDVSSGELALIILALGVCRNAEENLIYDYHLIDKLENKFQAEIENMEAHNGTPLTNYYQLSLDVLALCLFNGNYSTAEVVNHFTPENKNYYFGSQFSVDTGAMAVLALTCVKKSLINGQIKADEGSLKNISIYTKSLVEKILSEKKENGLIGNTFSTGEAMQALFVSSDYYNENDWNCQQTLNTVLTEISQGAFSNPNAAAQVLPALMGKTFLDINKDSSCVSASGNFNISADEPITVTPPDSQSYISVNYSVRINETYFTNVTVLNGSVFLSVMEKAQKMNDTIFGFTMEERSWGPYITCIQGLCANNNDRTYWELLSGGEPLSQGAGSYVVRNGENLEVRWSKY
Tag info: N-terminal 6xHis-SUMO-tagged
Expression Region: 24-433aa
Protein length: Full Length
MW: 61.6 kDa
Alternative Name(s): Haptocorrin Short name: HC Protein R Transcobalamin I Short name: TC I Short name: TCI
Relevance: Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach.
Reference: "Structural basis for universal corrinoid recognition by the cobalamin transport protein haptocorrin."Furger E., Frei D.C., Schibli R., Fischer E., Prota A.E.J. Biol. Chem. 288:25466-25476(2013)
Purity: Greater than 90% as determined by SDS-PAGE.
Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.
Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.