{"product_id":"vdr-ab-51-antibody-cat-csb-pa594723","title":"VDR (Ab-51) Antibody - Cat. #: CSB-PA594723","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:1 25 dihydroxyvitamin D3 receptor antibody; 1 antibody; 1,25 dihydroxyvitamin D3 receptor antibody; 1,25-@dihydroxyvitamin D3 receptor antibody; 25-dihydroxyvitamin D3 receptor antibody; Member 1 antibody; NR1I1 antibody; Nuclear receptor subfamily 1 group I member 1 antibody; PPP1R163 antibody; Protein phosphatase 1, regulatory subunit 163 antibody; VDR antibody; VDR_HUMAN antibody; Vitamin D (1,25- dihydroxyvitamin D3) receptor antibody; Vitamin D hormone receptor antibody; Vitamin D nuclear receptor variant 1 antibody; Vitamin D receptor antibody; Vitamin D3 receptor antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P11473\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Synthesized non-phosphopeptide derived from Human Vitamin D3 Receptor around the phosphorylation site of serine 51 (R-R-S(p)-M-K).\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:3000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Nuclear hormone receptor. Transcription factor that mediates the action of vitamin D3 by controlling the expression of hormone sensitive genes. Regulates transcription of hormone sensitive genes via its association with the WINAC complex, a chromatin-remodeling complex. Recruited to promoters via its interaction with the WINAC complex subunit BAZ1B\/WSTF, which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.\u003cbr\u003e\u003cbr\u003eBaker A.R., Proc. Natl. Acad. Sci. U.S.A. 85:3294-3298(1988).\u003cbr\u003eGoto H., Biochim. Biophys. Acta 1132:103-108(1992).\u003cbr\u003eMiyamoto K., Mol. Endocrinol. 11:1165-1179(1997).\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:VDR\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Cancer;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483695591524,"sku":"CSB-PA594723","price":867.34,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_feb478c8-fc38-4701-8cad-6076ca833284.jpg?v=1660074068","url":"https:\/\/www.genebiosystems.com\/products\/vdr-ab-51-antibody-cat-csb-pa594723","provider":"GeneBio ","version":"1.0","type":"link"}