{"product_id":"trim25-antibody-cat-csb-pa997812","title":"TRIM25 Antibody - Cat. #: CSB-PA997812","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:E3 ubiquitin\/ISG15 ligase TRIM25 antibody; EFP antibody; Estrogen responsive finger protein antibody; Estrogen-responsive finger protein antibody; RING finger protein 147 antibody; RNF 147 antibody; RNF147 antibody; TRI25 antibody; TRI25_HUMAN antibody; TRIM 25 antibody; Trim25 antibody; Tripartite motif containing 25 antibody; Tripartite motif containing protein 25 antibody; Tripartite motif protein TRIM25 antibody; Tripartite motif-containing protein 25 antibody; Tripartite motifcontaining25 antibody; Ubiquitin\/ISG15-conjugating enzyme TRIM25 antibody; Z147 antibody; Zinc finger protein 147 (estrogen responsive finger protein) antibody; Zinc finger protein 147 antibody; Zinc finger protein-147 antibody; ZNF 147 antibody; ZNF147 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q14258\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Synthesized peptide derived from internal of Human ZNF147.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:3000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs.\u003cbr\u003e\u003cbr\u003eInoue S., Proc. Natl. Acad. Sci. U.S.A. 90:11117-11121(1993).\u003cbr\u003eThe MGC Project Team, Genome Res. 14:2121-2127(2004).\u003cbr\u003eRush J., Nat. Biotechnol. 23:94-101(2005).\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:TRIM25\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling;Cell biology;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483710337124,"sku":"CSB-PA997812","price":867.34,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_d699c3e8-1bfc-459c-800c-1c755b2eaae2.jpg?v=1660074405","url":"https:\/\/www.genebiosystems.com\/products\/trim25-antibody-cat-csb-pa997812","provider":"GeneBio ","version":"1.0","type":"link"}