{"product_id":"smad7-antibody-biotin-conjugated-cat-csb-pa021793ld01hu","title":"SMAD7 Antibody, Biotin conjugated - Cat. #: CSB-PA021793LD01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:CRCS3 antibody; FLJ16482 antibody; hSMAD 7 antibody; hSMAD7 antibody; MAD (mothers against decapentaplegic Drosophila) homolog 7 antibody; MAD antibody; Mad homolog 7 antibody; MAD homolog 8 antibody; MAD mothers against decapentaplegic homolog 7 antibody; MADH 7 antibody; MADH 8 antibody; MADH6 antibody; MADH7 antibody; MADH8 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 6 antibody; Mothers Against Decapentaplegic Drosophila Homolog of 7 antibody; Mothers against decapentaplegic homolog 7 antibody; Mothers against decapentaplegic homolog 8 antibody; Mothers against DPP homolog 7 antibody; Mothers against DPP homolog 8 antibody; SMA- AND MAD-RELATED PROTEIN 7 antibody; SMAD 7 antibody; SMAD antibody; SMAD family member 7 antibody; SMAD, mothers against DPP homolog 7 (Drosophila) antibody; SMAD, mothers against DPP homolog 7 antibody; SMAD6 antibody; Smad7 antibody; SMAD7_HUMAN antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O15105\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Mothers against decapentaplegic homolog 7 protein (36-247AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Biotin\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SMAD7\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling; Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40487710883940,"sku":"CSB-PA021793LD01HU","price":484.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_6e95afee-6295-49c4-9967-f54a24a6799d.jpg?v=1660169121","url":"https:\/\/www.genebiosystems.com\/products\/smad7-antibody-biotin-conjugated-cat-csb-pa021793ld01hu","provider":"GeneBio ","version":"1.0","type":"link"}