{"product_id":"recombinant-phospho-her2-erbb2-tyr1221-1222-monoclonal-antibody","title":"Recombinant Phospho-HER2\/ErbB2 (Tyr1221, 1222) Monoclonal Antibody","description":"\u003cp\u003e\u003cb\u003eSize:\u003c\/b\u003e:20μL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e:Ice bag\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e:12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e:Primary Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e:Recombinant Antibodies\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e:ERBB2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e:TKR;ERBB;erb-b2 receptor tyrosine kinase;Receptor tyrosine-protein kinase erbB;Tyrosine kinase-type cell surface receptor HER;HER2\/ErbB;HER;MLN;ERBB2;CD340;HER-2;HER-2\/neu;HER2;MLN 19;NEU;NGL;TKR1;erb-b2 receptor tyrosine kinase 2;HER2\/ErbB2;MLN19;Metastatic lymph node gene 19 protein;p185;Proto-oncogene Neu;Receptor tyrosine-protein kinase erbB-2;Tyrosine kinase-type cell surface receptor HER2;Neu;erb-B2;CD340;erb-b2 receptor tyrosine kinase 2;HER2;HER-2;HER-2\/neu;MLN 19;MLN19;NGL;TKR1;C erb B2\/neu protein;CD340 antigen;Cerb B2\/neu protein;CerbB2;ENV;ENVW;Erb b2 receptor tyrosine kinase 2;ERVWE1;HER 2;HER 2\/NEU;Herstatin;HERV7Q;HERV-7q;HERVW;HERVWENV;HERV-W-ENV;Human epidermal growth factor receptor 2;NEU proto oncogene;neuro\/glioblastoma derived oncogene homolog;neuro\/glioblastoma derived oncogene homolog (avian);Neuroblastoma\/glioblastoma derived oncogene homolog;p185erbB2;Proto-oncogene c-ErbB-2;Tyrosine kinase type cell surface receptor HER2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2;V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro\/glioblastoma derived oncogene homolog);V erb b2 avian erythroblastic leukemia viral oncoprotein 2;V erb b2 erythroblastic leukemia viral oncogene homolog 2;Verb b2 erythroblastic leukemia viral oncogene homolog 2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Tags \u0026amp; Cell Markers;Signal Transduction;Cancer\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e:Unconjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e:WB\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Rabbit Monoclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone NO.\u003c\/b\u003e:1A9\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e:P04626\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:ErbB2, also called Neu and Her2, is a transmembrane glycoprotein in the ErbB family of tyrosine kinase receptors for EGF superfamily growth factors. ErbB2 is widely expressed in epithelial cells and over-expressed in a large number of breast carcinomas. ErbB2 has no identified ligands but heterodimerizes with ErbB1\/EGF R, ErbB3, or ErbB4 to form higher affinity signaling complexes. The protease ADAM10 releases a 110 kDa soluble fragment of ErbB2 from the cell surface. ErbB2 plays roles in development, cancer, communication at the neuromuscular junction, and regulation of cell growth and differentiation. The ErbB2\/ErbB3 heterodimer is expressed in the majority of breast, skin, ovary and gastrointestinal tumors and transduces a highly mitogenic signal in response to neuregulin 1 (NRG1; heuregulin 1) or NRG2. ErbB3, ErbB2 and neuregulin are all required for formation of the sympathetic nervous system.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e:1 mg\/mL\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:A synthetic phosphopeptide corresponding to residues around (Tyr1221, 1222) of human HER2\/ErbB2.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:10 mM sodium HEPES, 150 mM NaCl, 100 μg\/mL protein protectant, 50% glycerol, pH 7.5\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification method\u003c\/b\u003e:Protein A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDilution\u003c\/b\u003e:WB 1:10000-1:200000;\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e:138 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e:220 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48644712595556,"sku":"AN300005L","price":308.7,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_409382b4-9ff4-4344-8d95-aa89b63a34c4.jpg?v=1782651644","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-phospho-her2-erbb2-tyr1221-1222-monoclonal-antibody","provider":"GeneBio ","version":"1.0","type":"link"}