{"product_id":"recombinant-mouse-ptpn2-ptpt-protein-aa-2-314-his-tag","title":"Recombinant Mouse PTPN2\/PTPT Protein (aa 2-314, His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: AI325124;Ptpt;TC-PTP\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Enzyme\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q06180\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q06180-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Tyrosine-protein phosphatase  non-receptor type 2, also known as T-cell protein-tyrosine phosphatase, PTPN2  and PTPT, is a cytoplasm protein which belongs to theprotein-tyrosine  phosphatase family and Non-receptor class 1 subfamily. Members of the protein  tyrosine phosphatase ( PTP ) family share a highly conserved catalytic motif,  which is essential for the catalytic activity. TC-PTP \/ PTPN2 is a cytosolic  tyrosine phosphatase that functions as a negative regulator of a variety of  tyrosine kinases and other signaling proteins. The expression of TC-PTP \/ PTPN2  plays a role of tumor suppressor and may modulate response to treatment. PTPs  are known to be signaling molecules that regulate a variety of cellular  processes including cell growth, differentiation, mitotic cycle, and oncogenic  transformation. Epidermal growth factor receptor and the adaptor protein Shc  were reported to be substrates of this PTP, which suggested the roles in growth  factor mediated cell signaling. TC-PTP \/ PTPN2 is an enzyme that is essential  for the proper functioning of the immune system and that participates in the  control of cell proliferation, and inflammation.TC-PTP \/ PTPN2 was  identified as a negative regulator of NUP214-ABL1 kinase activity.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured by its ability to dephosphorylate a phosphotyrosine residue in an EGF receptor 988-998 phosphopeptide substrate, R\u0026amp;D Systems, Catalog # ES006. The specific activity is \u0026gt; 15 nmoles\/min\/μg. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Ser 2-Asn 314\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 20mM Tris, 500mM NaCl, pH 8.0, 20% glycerol, 0.1mM TCEP\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 38.7 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 42 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47986025103460,"sku":"PKSM040482","price":1368.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_98aec8b3-97f3-4cad-9b9c-acd4abb98943.jpg?v=1772479846","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-mouse-ptpn2-ptpt-protein-aa-2-314-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}