{"product_id":"recombinant-mouse-hpgd-15-pgdh-protein-his-tag","title":"Recombinant Mouse HPGD\/15-PGDH Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: 15-PGDH;AV026552\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: ELISA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q8VCC1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q8VCC1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: 15-hydroxyprostaglandin  dehydrogenase [NAD+], also known as Prostaglandin dehydrogenase 1, HPGD, and  PGDH1, is a member of the short-chain dehydrogenases\/reductases (SDR) family.  Prostaglandins (PGs) play a key role in the onset of labor inmany species  and regulate uterine contractility and cervicaldilatation. Therefore, the  regulation of prostaglandin outputby PG synthesizing and metabolizing  enzymes in the human myometrium may determine uterine activitypatterns in  human labor both at preterm and at term. Prostaglandin dehydrogenase (PGDH)  metabolizes prostaglandins (PGs) to render them inactive. HPGD is  down-regulated by cortisol, dexamethasone and betamethasone and down-regulated  in colon cancer. It is up-regulated by TGFB1. HPGD contributes to the  regulation of events that are under the control of prostaglandin levels. HPGD  catalyzes the NAD-dependent dehydrogenation of lipoxin A4 to form  15-oxo-lipoxin A4. and inhibits in vivo proliferation of colon cancer cells.  Defects in HPGD are the cause of primary hypertrophic osteoathropathy autosomal  recessive (PHOAR), cranioosteoarthropathy (COA),and isolated  congenital nail clubbing.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured by its ability to bind Rhesus ErbB3-His in functional Elisa. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Ser 269\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 8.0, 20% glycerol\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 30.6 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 30 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47986068553828,"sku":"PKSM040631","price":1224.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_02511937-6348-452e-942c-1b4263fac146.jpg?v=1772480762","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-mouse-hpgd-15-pgdh-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}