{"product_id":"recombinant-human-xrcc5-xrcc6-heterodimer-protein","title":"Recombinant Human XRCC5 \u0026 XRCC6 Heterodimer Protein","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: KARP-1;KARP1;KU80;KUB2;Ku86;NFIV\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Cancer;epigenetics and nuclear signal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P13010;P12956\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: P13010\u0026amp;P12956\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: X-ray repair cross-complementing  protein 5, also known as 86 kDa subunit of Ku antigen, ATP-dependent DNA  helicase 2 subunit 2, ATP-dependent DNA helicase II 80 kDa subunit, CTC  box-binding factor 85 kDa subunit, DNA repair protein XRCC5, Lupus Ku autoantigen  protein p86, TLAA and XRCC5, is a nucleus and chromosome which belongs to  theku80 family. XRCC5 is a single stranded DNA-dependent ATP-dependent  helicase. XRCC5 has a role in chromosome translocation. X-ray repair cross-complementing  protein 6, also known as 5'-deoxyribose-5-phosphate lyase Ku70, ATP-dependent  DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, 70 kDa  subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, CTC box-binding  factor 75 kDa subunit, Lupus Ku autoantigen protein p70, Thyroid-lupus  autoantigen and XRCC6, is a nucleus and chromosome which belongs to  theku70 family. Heterodimer of a XRCC6 and a XRCC5  subunit associates in a DNA-dependent manner with PRKDC to form the  DNA-dependent protein kinase complex DNA-PK, and with the LIG4-XRCC4 complex.  The dimer also associates with NAA15, and this complex binds to the osteocalcin  promoter and activates osteocalcin expression.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Ile732\u0026amp;Met 1-Asp609\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 20mM Tris, 500mM NaCl, 10% glycerol, pH 8.0\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 85\u0026amp;72 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 70 \u0026amp; 85 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972829266020,"sku":"PKSH030480","price":1224.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_7f643dd8-6bd3-47c1-a032-26313ff899af.jpg?v=1772198564","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-xrcc5-xrcc6-heterodimer-protein","provider":"GeneBio ","version":"1.0","type":"link"}