{"product_id":"recombinant-human-xedar-eda2r-protein-his-tag","title":"Recombinant Human XEDAR\/EDA2R Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: EDA-A2R;EDAA2R;TNFRSF27;XEDAR\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction;Cell biology;Cancer;Stem cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q9HAV5\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_068555.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Tumor necrosis factor receptor  superfamily member 27, also known as X-linked ectodysplasin-A2 receptor, EDA-A2  receptor, EDA2R, XEDAR and TNFRSF27, is a single-pass type III membrane  protein. TNFRSF27 \/ EDA2R contains threeTNFR-Cys repeats. It is a new  member of the tumor necrosis factor receptor family that has been shown to be  highly expressed in ectodermal derivatives during embryonic development and  binds to ectodysplasin-A2 (EDA-A2). TNFRSF27 \/ EDA2R is a receptor for EDA  isoform A2, but not for EDA isoform A1. TNFRSF27 \/ EDA2R mediates the  activation of the NF-kappa-B and JNK pathways. The activation seems to be  mediated by binding to TRAF3 and TRAF6. Ectodysplasin, a member of the tumor  necrosis factor family, is encoded by the anhidrotic ectodermal dysplasia EDA  gene. Mutations in EDA give rise to a clinical syndrome characterized by loss  of hair, sweat glands, and teeth. EDA-A1 and EDA-A2 are two isoforms of  ectodysplasin that differ only by an insertion of two amino acids. This insertion  functions to determine receptor binding specificity, such that EDA-A1 binds  only the receptor EDAR, whereas EDA-A2 binds only the related, but distinct,  X-linked ectodysplasin-A2 receptor (XEDAR).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Thr 138\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 16.7 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 33 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972883267684,"sku":"PKSH030983","price":1224.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_e4f01287-446f-4d81-b417-bc455e95d843.jpg?v=1772201226","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-xedar-eda2r-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}