Recombinant Human  Tumor protein 63(TP63)

Recombinant Human Tumor protein 63(TP63)

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Size: 200ug. Other sizes are also available. Please Inquire.

In Stock: No

Lead time: 10-20 working days

Research Topic: Apoptosis

Uniprot ID: Q9H3D4

Gene Names: TP63

Organism: Homo sapiens (Human)


Expression Region: 1-680aa

Sequence Info: Full Length

Source: E.coli

Tag Info: N-terminal 6xHis-tagged

MW: 80.8 kDa

Alternative Name(s): Chronic ulcerative stomatitis protein ;CUSPKeratinocyte transcription factor KETTransformation-related protein 63 ;TP63Tumor protein p73-like ;p73Lp40p51

Relevance: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. Isoform 2 activates RIPK4 transcription. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial st cell compartments and regulate the initiation of epithelial stratification from the undifferentiated bryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter

Reference: A second p53-related protein, p73L, with high homology to p73.Senoo M., Seki N., Ohira M., Sugano S., Watanabe M., Tachibana M., Tanaka T., Shinkai Y., Kato H.Biochem. Biophys. Res. Commun. 248:603-607(1998)

Purity: Greater than 90% as determined by SDS-PAGE.

Storage Buffer: Tris-based buffer,50% glycerol

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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