{"product_id":"recombinant-human-thioredoxin-2-txn2-protein-his-tag","title":"Recombinant Human Thioredoxin-2\/TXN2 Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: MTRX;Mt-Trx;TRX2;TXN2;Thioredoxin Mitochondrial;Thioredoxin-2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction;Cancer;metabolism;\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Enzyme\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q99757\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q99757\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Thioredoxin-2;  also known as TXN2; MTRX and TRX2; is a member of the thioredoxin family.  Tryparedoxins (TXN) are thioredoxin-related proteins which; as  trypanothione:peroxiredoxin oxidoreductases; constitute the  trypanothione-dependent antioxidant defense and may also serve as substrates  for ribonucleotide reductase in trypanosomatids. Thioredoxin-2 \/ TXN2 contains  onethioredoxin domain. It is widely expressed in adult (at protein level)  and fetal tissues. Human Thioredoxin-2 \/ TXN2 is a small redox protein  important in cellular antioxidant defenses; as well as in the regulation of  apoptosis. Thioredoxin-2 \/ TXN2 has an anti-apoptotic function and plays an  important role in the regulation of mitochondrial membrane potential.  Thioredoxin-2 \/ TXN2 could be involved in the resistance to anti-tumor agents.  It possesses a dithiol-reducing activity. Thioredoxin-2 \/ TXN2 plays an  important role in protecting the mitochondria against oxidative stress and in  sensitizing the cells to ROS-induced apoptosis. Mammalian Thioredoxin-2 \/ TXN2  is a mitochondrial isoform of highly evolutionary conserved thioredoxins.  Thioredoxins are small ubiquitous protein-disulfide oxidoreductases implicated  in a large variety of biological functions.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured by its ability to catalyze the reduction of insulin. The reaction leads to precipitation, which can be measured by absorbance at 650 nm. The specific activity is 5-8 A650\/min\/mg. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Thr 60-Gly 166\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 97 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 8.3\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 13.4 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 13 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972849385572,"sku":"PKSH030817","price":1224.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_b8c5fcb9-3a47-4987-a8c4-855ce8baf1d3.jpg?v=1772200362","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-thioredoxin-2-txn2-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}