{"product_id":"recombinant-human-taok3-jik-map3k18-protein-aa-1-411-his-gst-tag","title":"Recombinant Human TAOK3\/JIK\/MAP3K18 Protein (aa 1-411, His \u0026 GST Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: DPK;JIK;MAP3K18\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction,Epigenetics and Nuclear Signaling\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: Baculovirus-Insect Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Enzyme\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His-GST\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q9H2K8\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q9H2K8-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Serine\/threonine-protein  kinase TAO3, also known as cutaneous T-cell lymphoma-associated antigen  HD-CL-09, CTCL-associated antigen HD-CL-09, Dendritic cell-derived protein  kinase, JNK \/ SAPK-inhibitory kinase, Jun kinase-inhibitory kinase, Kinase from  chicken homolog A, Thousand and one amino acid protein 3, JIK, TAOK3 and  MAP3K18, is cytoplasm and peripheral membrane protein which belongs to  theprotein kinase superfamily, STE Ser\/Thr protein kinase family and  STE20 subfamily. Protein kinases are pivotal regulators of cell signaling that  modulate each other's functions and activities through site-specific  phosphorylation events. TAOK3 \/ JIK contains oneprotein kinase domain.  TAOK3 \/ JIK is ubiquitously expressed at a low level, and highly expressed in  peripheral blood leukocytes (PBLs), thymus, spleen, kidney, skeletal muscle,  heart and liver. TAOK3 \/ JIK inhibits the basal activity of Jun kinase. It is  negatively regulated by epidermal growth factor (EGF). When overexpressed,  TAOK3 \/ JIK may activate ERK1 \/ ERK2 and JNK \/ SAPK.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: The specific activity was determined to be 10 nmol\/min\/mg using synthetic PKCtide peptide (ERMRPRKRQGSVRRRV) as substrate. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Asp 411\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 92 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Supplied as sterile solution of 20mM Tris, 500mM NaCl, 3mM GSH, pH 7.4, 10% glycerol\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Not Applicable\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 74.3 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 85 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972819894372,"sku":"PKSH030364","price":1044.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_bec3bfc6-1dd0-43b3-9e90-7ff82a201fcc.jpg?v=1772197932","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-taok3-jik-map3k18-protein-aa-1-411-his-gst-tag","provider":"GeneBio ","version":"1.0","type":"link"}