{"product_id":"recombinant-human-sorcs1-protein-his-tag","title":"Recombinant Human SorCS1 Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: RP11-446H13.1;hSorCS\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Neuroscience,Signal Transduction\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: HEK293 Cells\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: C-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q8WY21\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: Q8WY21-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: VPS10  domain-containing receptor SorCS1, also known as SORCS1 and SORCS, is a  single-pass type I membrane protein which belongs to theSORCS family and  SORCS1 subfamily. SORCS1 contains fiveBNR repeats and onePKD  domain. SorCS1 is a member of the Vps10p-domain receptor family comprised of  Sortilin, SorCS1, SorCS2, SorCS3, and SorLA. The common characteristic of these  receptors is an N-terminal Vps10p domain, which either represents the only  module of the luminal\/extracellular moiety or is combined with additional  domains. Family members play roles in protein transport and signal  transduction. The individual receptors bind and internalize a variety of  ligands, such as neuropeptides and trophic factors, and Sortilin and SorLA  mediate trans-Golgi network-to-endosome sorting. Their prominent neuronal  expression, several of the identified ligands, and results support the notion  that members of this receptor family have important functions in neurogenesis,  plasticity-related processes, and functional maintenance of the nervous system.  Sortilin and SorLA mediate intracellular protein trafficking and sorting.  SorCS1 binds platelet-derived growth factor-BB (PDGF-BB) and is expressed in  isoforms differing only in their cytoplasmic domains. SorCS1 binds  platelet-derived growth factor, a growth factor crucial for pericyte  recruitment to the microvasculature, and may thus have a role in expanding or  maintaining the islet vasculature.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Ser 111-Ser 1099\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 92 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e:  \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 113 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 130 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972859904100,"sku":"PKSH030959","price":1224.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_3002fb36-01e5-4ca4-85d8-c5eed5ea123d.jpg?v=1772201095","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-sorcs1-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}