{"product_id":"recombinant-human-snap25-sup-protein-his-tag","title":"Recombinant Human SNAP25\/SUP Protein (His Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: RIC-4;RIC4;SEC9;SNAP;SNAP-25;bA416N4.2;dJ1068F16.2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Neuroscience,Signal Transduction,Cancer,Metabolism\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-His\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P60880\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: P60880-1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Synaptosomal-associated  protein 25, also known as Super protein, Synaptosomal-associated 25 kDa  protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein which  belongs to theSNAP-25 family. SNAP25 \/ SUP contains 2t-SNARE  coiled-coil homology domains. SNAP25 \/ SUP is a membrane bound protein anchored  to the cytosolic face of membranes via palmitoyl side chains in the middle of  the molecule. SNAP25 \/ SUP protein is a component of the SNARE complex, which  is proposed to account for the specificity of membrane fusion and to directly  execute fusion by forming a tight complex that brings the synaptic vesicle and  plasma membranes together. SNAP25 \/ SUP is a Q-SNARE protein contributing two  α-helices in the formation of the exocytotic fusion complex in neurons where it  assembles with syntaxin-1 and synaptobrevin. SNAP25 \/ SUP is involved in the  molecular regulation of neurotransmitter release. It may play an important role  in the synaptic function of specific neuronal systems. SNAP25 \/ SUP associates  with proteins involved in vesicle docking and membrane fusion. SNAP25 \/ SUP  regulates plasma membrane recycling through its interaction with CENPF. SNAP25  \/ SUP inhibits P\/Q- and L-type voltage-gated calcium channels located  presynaptically and interacts with the synaptotagmin C2B domain in  Ca2+-independent fashion. In glutamatergic synapses SNAP25 \/ SUP decreases the  Ca2+ responsiveness, while it is naturally absent in GABAergic synapses.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Gly 206\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 24.8 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 28 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972994285668,"sku":"PKSH031077","price":1044.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_ce28c4c5-3efa-4877-8c55-c93f5f63bcdc.jpg?v=1772201714","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-snap25-sup-protein-his-tag","provider":"GeneBio ","version":"1.0","type":"link"}