{"product_id":"recombinant-human-rtn4-nogo-a-protein-gst-tag","title":"Recombinant Human RTN4\/NOGO-A Protein (GST Tag)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 100μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: ASY;DGU;DKFZp781L1143;HIGM4;NI220\/250;NOGO;NOGO-A;NOGOC;NSP;NSP-CL;Nbla00271;Nbla10545;Nogo-B;Nogo-C;RTN-X;RTN4-A;RTN4-B1;RTN4-B2;RTN4-C;UDG;UNG1;UNG15;UNG2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Neuroscience\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: N-GST\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q9NQC3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_065393.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Reticulon-4,  also known as Foocen, Neurite outgrowth inhibitor, Nogo protein,  Neuroendocrine-specific protein, Neuroendocrine-specific protein C homolog,  RTN-x, Reticulon-5 and RTN4, is a multi-pass membrane protein which contains  onereticulon domain. Isoform1of RTN4 is specifically  expressed in brain and testis and weakly in heart and skeletal muscle.  Isoform2 of RTN4 is widely expressed except for the liver.  Isoform3of RTN4 is expressed in brain, skeletal muscle and  adipocytes. Isoform4of RTN4 is testis-specific. Reticulon-4 \/ RTN4  is a developmental neurite growth regulatory factor with a role as a negative  regulator of axon-axon adhesion and growth, and as a facilitator of neurite  branching. Reticulon-4 \/ RTN4 regulates neurite fasciculation, branching and  extension in the developing nervous system. Reticulon-4 \/ RTN4 is involved in  down-regulation of growth, stabilization of wiring and restriction of  plasticity in the adult CNS. It regulates the radial migration of cortical  neurons via an RTN4R-LINGO1 containing receptor complex. Isoform 2 of RTN4  reduces the anti-apoptotic activity of Bcl-xl and Bcl-2. This is likely  consecutive to their change in subcellular location, from the mitochondria to  the endoplasmic reticulum, after binding and sequestration. Isoform 2 and  isoform 3 of RTN4 inhibit BACE1 activity and amyloid precursor protein  processing.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Met 1-Val 185\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 70 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 20mM Tris, 150mM NaCl, 1mM DTT, 0.2mM GSH, pH 7.0\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 46.2 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 48 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972845682788,"sku":"PKSH030757","price":1224.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_f8cfe6a2-8cf2-401a-a3de-f7780641988d.jpg?v=1772200016","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-rtn4-nogo-a-protein-gst-tag","provider":"GeneBio ","version":"1.0","type":"link"}