{"product_id":"recombinant-human-ido1-ido-protein","title":"Recombinant Human IDO1\/IDO Protein","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Immune Checkpoint Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: 3-dioxygenase;3-dioxygenase 1;IDO;IDO-1;IDO1;INDO;Indole 2;Indoleamine 2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction;Cardiovascular;Cancer;metabolism;\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: Enzyme\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: None\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: P14902\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_002155.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Indoleamine 2,3-dioxygenase-1, also known as Indoleamine-pyrrole 2,3-dioxygenase, IDO1 and IDO, is a  member of the indoleamine 2,3-dioxygenase family. IDO1 \/ IDO  and tryptophan 2,3-dioxygenase (TDO) are tryptophan-degrading enzymes that  catalyze the first step in tryptophan catabolism via the kynurenine pathway. TDO is widely distributed  in both eukaryotes and bacteria. In contrast, IDO has been found only in  mammals and yeast. In 2007, a third enzyme, indoleamine 2,3-dioxygenase-2 (IDO2), was discovered. IDO2 is found  not only in mammals but also in lower vertebrates. IDO1 \/ IDO is an  immunosuppressive molecule inducible in various cells. IDO1 \/ IDO catalyzes the  cleavage of the pyrrol ring of tryptophan and incorporates  both atoms of a molecule of oxygen. It mediates oxidative cleavage of  tryptophan, an amino acid essential for cell proliferation and survival. IDO1 \/  IDO inhibition is proposed to have therapeutic potential in immunodeficiency-associated  abnormalities, including cancer. The IDO pathway is activated in multiple tumor  types. Selective inhibition of IDO1 may represent an attractive cancer  therapeutic strategy via up-regulation of cellular immunity. IDO1 \/ IDO is an  enzyme that suppresses adaptive T-cell immunity by catabolizing tryptophan from the cellular  microenvironment. Inhibition of IDO pathway might enhance the efficacy of  immunotherapeutic strategies for cancer\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Measured by its ability to oxidize L-tryptophan to N-formylk-ynurenine. The specific activity is \u0026gt; 500 pmoles\/min\/μg. \u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Ala2-Gly403\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Supplied as sterile solution of 50 mM NaAC, 100 mM Nacl, 20 % glycerol, pH 5.5.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Not Applicable\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 45.2 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 46 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972819533924,"sku":"PKSH030355","price":1044.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_b155271b-0da1-4d13-b440-b3045b015ba2.jpg?v=1772197879","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-ido1-ido-protein","provider":"GeneBio ","version":"1.0","type":"link"}