Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2),partial

Recombinant Human Hepatitis A virus cellular receptor 2(HAVCR2),partial

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Size: 200ug. Other sizes are also available. Please Inquire.

In Stock: No

Lead time: 22-32 working days

Research Topic: Immunology

Uniprot ID: Q8TDQ0

Gene Names: HAVCR2

Organism: Homo sapiens (Human)


Expression Region: 22-202aa

Sequence Info: Extracellular Domain

Source: Yeast

Tag Info: N-terminal 6xHis-tagged

MW: 22 kDa

Alternative Name(s): T-cell immunoglobulin and mucin domain-containing protein 3 ;TIMD-3T-cell immunoglobulin mucin receptor 3 ;TIM-3T-cell membrane protein 3

Relevance: Regulates macrophage activation. Inhibits T-helper type 1 lymphocyte (Th1)-mediated auto- and alloimmune responses and promotes immunological tolerance. May be also involved in T-cell homing. Receptor for LGALS9.

Reference: Th1-specific cell surface protein Tim-3 regulates macrophage activation and severity of an autoimmune disease.Monney L., Sabatos C.A., Gaglia J.L., Ryu A., Waldner H., Chernova T., Manning S., Greenfield E.A., Coyle A.J., Sobel R.A., Freeman G.J., Kuchroo V.K.Nature 415:536-541(2002)

Purity: Greater than 90% as determined by SDS-PAGE.

Storage Buffer: Tris-based buffer,50% glycerol

Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20℃/-80℃. The shelf life of lyophilized form is 12 months at -20℃/-80℃.

Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.

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