{"product_id":"recombinant-human-camk1-camki-alpha-protein","title":"Recombinant Human CAMK1\/CaMKI-alpha Protein","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e: 50μg\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage\u003c\/b\u003e: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eShipping\u003c\/b\u003e: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExp date\u003c\/b\u003e: 12 months\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_II\u003c\/b\u003e: Recombinant Proteins\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCategory ID_III\u003c\/b\u003e: Others\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAbbreviation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Synonym\u003c\/b\u003e: CAMK1;CaM Kinase I;CaM Kinase I Alpha;CaM-KI;CaMKI-Alpha;Calcium\/Calmodulin-Dependent Protein Kinase Type 1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e: Signal Transduction;Cardiovascular;Neuroscience;\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugation\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Species\u003c\/b\u003e: Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eExpression Host\u003c\/b\u003e: E.coli\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplication\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eFusion tag\u003c\/b\u003e: None\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUNIProt ID\u003c\/b\u003e: Q14012\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e: NP_003647.1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e: Calcium\/calmodulin-dependent  protein kinase orCaM kinases are serine\/threonine-specific protein  kinasesthat are primarily regulated by the Calcium\/calmodulin complex.  These kinases show a memory effect on activation. CaM kinases activity can outlast  the intracellular calcium transient that is needed to activate it.  Inneurons, this property is important for the induction of synaptic  plasticity. Pharmacological inhibition of CaM kinases II blocks the induction  oflong-term potentiation. Upon activation, CaM kinases II phosphorylates  postsynaptic glutamate receptors and changes the electrical properties of the  synapse. Calcium\/calmodulin-dependent protein  kinase type 1D, also known as CaM kinase I delta, CaM kinase ID, CaMKI-like  protein kinase, CKLiK and CAMK1D, is a member of theprotein kinase  superfamily and CaMK subfamily. It contains oneprotein kinase domain.  CAMK1D is broadly expressed. It is highly and mostly expressed in  polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while  little or no expression is observed in monocytes and lymphocytes. Engineered  overexpression of CAMK1D in non-tumorigenic breast epithelial cells led to  increased cell proliferation, and molecular and phenotypic alterations  indicative of epithelial-mesenchymal transition (EMT), including loss of  cell-cell adhesions and increased cell migration and invasion. CAMK1D is a  potential therapeutic target with particular relevance to clinically  unfavorable basal-like tumors.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConcentration\u003c\/b\u003e: \u003c\/p\u003e\u003cp\u003e\u003cb\u003eActivity\u003c\/b\u003e: Not validated for activity\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSequence\u003c\/b\u003e: Leu 2-Leu 370\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:  \u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eFormulation\u003c\/b\u003e: Lyophilized from sterile 50mM Tirs, 150mM NaCl, 10% glycerol, pH 7.5\u003cbr\u003eNormally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.\u003cbr\u003ePlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eReconstitution\u003c\/b\u003e: Please refer to the printed manual for detailed information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin\u003c\/b\u003e: Please contact us for more information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eCalculated MW\u003c\/b\u003e: 41.5 kDa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eObservedMW\u003c\/b\u003e: 42 kDa\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":47972828643428,"sku":"PKSH030469","price":788.4,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_2890ad94-4cb7-422f-8705-77480b26f20a.jpg?v=1772198505","url":"https:\/\/www.genebiosystems.com\/products\/recombinant-human-camk1-camki-alpha-protein","provider":"GeneBio ","version":"1.0","type":"link"}