{"product_id":"ptpn22-antibody-cat-csb-pa780242","title":"PTPN22 Antibody - Cat. #: CSB-PA780242","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Hematopoietic cell protein tyrosine phosphatase 70Z PEP antibody; Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP antibody; Lymphoid phosphatase antibody; Lymphoid specific protein tyrosine phosphatase antibody; lymphoid-specific; inducible human protein tyrosine phosphatase antibody; Lyp 1 antibody; Lyp 2 antibody; LyP antibody; Lyp1 antibody; Lyp2 antibody; LyPTP antibody; OTTHUMP00000013720 antibody; OTTHUMP00000013721 antibody; OTTHUMP00000233450 antibody; OTTHUMP00000233451 antibody; PEP antibody; PEST-domain phosphatase antibody; Protein tyrosine phosphatase non receptor type 22 (lymphoid) antibody; Protein tyrosine phosphatase non receptor type 22 antibody; Protein tyrosine phosphatase non receptor type 8 antibody; Protein tyrosine phosphatase non receptor type 8; formerly antibody; PTN22_HUMAN antibody; PTPN 22 antibody; PTPN 8 antibody; Ptpn22 antibody; PTPN8 antibody; PTPN8; formerly antibody; Tyrosine-protein phosphatase non-receptor type 22 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q9Y2R2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Synthesized peptide derived from Internal of Human PTPN22.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB; WB:1:500-1:3000\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Acts as negative regulator of T-cell receptor (TCR) signaling by direct dephosphorylation of the Src family kinases LCK and FYN, ITAMs of the TCRz\/CD3 complex, as well as ZAP70, VAV, VCP and other key signaling molecules. Associates with and probably dephosphorylates CBL. Dephosphorylates LCK at its activating 'Tyr-394' residue. Dephosphorylates ZAP70 at its activating 'Tyr-493' residue. Dephosphorylates the immune system activator SKAP2.\u003cbr\u003e\u003cbr\u003eCohen S., Blood 93:2013-2024(1999).\u003cbr\u003eLiu T., Submitted (JUL-1998) to the EMBL\/GenBank\/DDBJ databases.\u003cbr\u003eWang S., Submitted (JAN-2010) to the EMBL\/GenBank\/DDBJ databases.\u003cbr\u003e \u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:PTPN22\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483762110564,"sku":"CSB-PA780242","price":867.34,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_23bf6b75-17ce-426d-a0a3-a9d72fd68794.jpg?v=1660075632","url":"https:\/\/www.genebiosystems.com\/products\/ptpn22-antibody-cat-csb-pa780242","provider":"GeneBio ","version":"1.0","type":"link"}