{"product_id":"psme3-antibody-cat-csb-pa13674a0rb","title":"PSME3 Antibody - Cat. #: CSB-PA13674A0Rb","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:11S regulator complex gamma subunit antibody; 11S regulator complex subunit gamma antibody; Activator of multicatalytic protease subunit 3 antibody; Ki antibody; Ki antigen antibody; Ki nuclear autoantigen antibody; Ki, PA28 gamma antibody; PA28 gamma antibody; PA28g antibody; PA28gamma antibody; Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antibody; Proteasome (prosome, macropain) activator subunit 3 antibody; Proteasome activator 28 gamma antibody; Proteasome activator 28 subunit gamma antibody; Proteasome activator complex subunit 3 antibody; Proteasome activator subunit 3 antibody; PSME3 antibody; PSME3_HUMAN antibody; REG GAMMA antibody; REG-gamma antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P61289\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Proteasome activator complex subunit 3 protein (2-252AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53\/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53\/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:PSME3\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cancer; Cell biology; Immunology\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484846305380,"sku":"CSB-PA13674A0Rb","price":484.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_43f5ab37-5b8f-48c3-aa84-99361ef09a78.jpg?v=1660108524","url":"https:\/\/www.genebiosystems.com\/products\/psme3-antibody-cat-csb-pa13674a0rb","provider":"GeneBio ","version":"1.0","type":"link"}