{"product_id":"prkra-antibody-cat-csb-pa13669a0rb","title":"PRKRA Antibody - Cat. #: CSB-PA13669A0Rb","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:DYT16 antibody; HSD14 antibody; Interferon inducible double stranded RNA dependent protein kinase activator A antibody; interferon-inducible double stranded RNA-dependent activator antibody; Interferon-inducible double stranded RNA-dependent protein kinase activator A antibody; PACT antibody; PKR associated protein X antibody; PKR associating protein X antibody; PKR-associated protein X antibody; PKR-associating protein X antibody; PRKRA antibody; PRKRA_HUMAN antibody; Protein activator of the interferon induced protein kinase antibody; Protein activator of the interferon-induced protein kinase antibody; Protein kinase antibody; Protein kinase interferon inducible double stranded RNA dependent activator antibody; RAX antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O75569\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Interferon-inducible double-stranded RNA-dependent protein kinase activator A protein (1-313AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:500\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Activates EIF2AK2\/PKR in the absence of double-stranded RNA (dsRNA), leading to phosphorylation of EIF2S1\/EFI2-alpha and inhibition of translation and induction of apoptosis. Required for siRNA production by DICER1 and for subsequent siRNA-mediated post-transcriptional gene silencing. Does not seem to be required for processing of pre-miRNA to miRNA by DICER1. Promotes UBC9-p53\/TP53 association and sumoylation and phosphorylation of p53\/TP53 at \\\\\\'Lys-386\\\\\\' at \\\\\\'Ser-392\\\\\\' respectively and enhances its activity in a EIF2AK2\/PKR-dependent manner (By similarity).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:PRKRA\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40484846174308,"sku":"CSB-PA13669A0Rb","price":484.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_d549d474-194a-4b9e-bbd6-85bfe6755bd5.jpg?v=1660108518","url":"https:\/\/www.genebiosystems.com\/products\/prkra-antibody-cat-csb-pa13669a0rb","provider":"GeneBio ","version":"1.0","type":"link"}