{"product_id":"pik3r2-antibody-cat-csb-pa018005la01hu","title":"PIK3R2 Antibody - Cat. #: CSB-PA018005LA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:p85 antibody; p85 beta antibody; P85B antibody; P85B_HUMAN antibody; Phosphatidylinositol 3 kinase antibody; Phosphatidylinositol 3 kinase regulatory beta subunit  antibody; Phosphatidylinositol 3 kinase regulatory subunit beta antibody; Phosphatidylinositol 3 kinase regulatory subunit polypeptide 2 antibody; Phosphatidylinositol 3 kinase; regulatory subunit; polypeptide 2 (p85 beta) antibody; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit beta antibody; Phosphatidylinositol 3-kinase regulatory subunit beta antibody; Phosphoinositide 3 kinase regulatory subunit 2 (beta) antibody; Phosphoinositide 3 kinase regulatory subunit 2 antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 2 (p85 beta) antibody; Phosphoinositide 3 kinase regulatory subunit polypeptide 2 antibody; Phosphoinositide 3 kinase; regulatory subunit 2 (beta) antibody; Phosphoinositide 3 kinase; regulatory subunit 2 (p85 beta) antibody; PI3 kinase p85 beta subunit  antibody; PI3 kinase p85 subunit beta antibody; PI3-kinase regulatory subunit beta antibody; PI3-kinase subunit p85-beta antibody; PI3K antibody; PI3K regulatory subunit beta antibody; PIK3R 2 antibody; PIK3R2 antibody; PtdIns 3 kinase p85 beta antibody; PtdIns-3-kinase regulatory subunit beta antibody; PtdIns-3-kinase regulatory subunit p85-beta antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:O00459\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Phosphatidylinositol 3-kinase regulatory subunit beta protein (75-125AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Regulatory subunit of phosphoinositide-3-kinase (PI3K), a kinase that phosphorylates PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Binds to activated (phosphorylated) protein-tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane. Indirectly regulates autophagy (PubMed:23604317). Promotes nuclear translocation of XBP1 isoform 2 in a ER stress- and\/or insulin-dependent manner during metabolic overloading in the liver and hence plays a role in glucose tolerance improvement (By similarity).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:PIK3R2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Immunology; Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486829064292,"sku":"CSB-PA018005LA01HU","price":484.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_02b603fa-13d3-4c5b-8ce4-d38a0338def7.jpg?v=1660154307","url":"https:\/\/www.genebiosystems.com\/products\/pik3r2-antibody-cat-csb-pa018005la01hu","provider":"GeneBio ","version":"1.0","type":"link"}