{"product_id":"kmt5a-antibody-fitc-conjugated-cat-csb-pa889082lc01hu","title":"KMT5A Antibody, FITC conjugated - Cat. #: CSB-PA889082LC01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:H4 K20 HMTase antibody; H4 K20 specific histone methyltransferase antibody; H4-K20-HMTase SETD8 antibody; Histone H4 K20 methyltransferase antibody; Histone lysine N methyltransferase H4 lysine 20 specific antibody; Histone-lysine N-methyltransferase SETD8 antibody; Lysine N-methyltransferase 5A antibody; N-lysine methyltransferase SETD8 antibody; Pr SET 7 antibody; Pr SET7 antibody; PR-Set7 antibody; PR\/SET domain containing protein 07 antibody; PR\/SET domain containing protein 8 antibody; PR\/SET domain-containing protein 07 antibody; PR\/SET07 antibody; PrSET7 antibody; SET 07 antibody; SET 8 antibody; SET domain containing (lysine methyltransferase) 8 antibody; SET domain containing 8 antibody; SET domain containing lysine methyltransferase 8 antibody; SET domain containing protein 8 antibody; SET domain-containing protein 8 antibody; SET07 antibody; SET8 antibody; SETD 8 antibody; setd8 antibody; SETD8_HUMAN antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q9NQR1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human N-lysine methyltransferase KMT5A protein (136-258AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Protein-lysine N-methyltransferase that monomethylates both histones and non-histone proteins. Specifically monomethylates \\\\\\'Lys-20\\\\\\' of histone H4 (H4K20me1). H4K20me1 is enriched during mitosis and represents a specific tag for epigenetic transcriptional repression. Mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. Required for cell proliferation, probably by contributing to the maintenance of proper higher-order structure of DNA during mitosis. Involved in chromosome condensation and proper cytokinesis. Nucleosomes are preferred as substrate compared to free histones. Mediates monomethylation of p53\/TP53 at \\\\\\'Lys-382\\\\\\', leading to repress p53\/TP53-target genes. Plays a negative role in TGF-beta response regulation and a positive role in cell migration.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:FITC\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, PH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:KMT5A\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486404325476,"sku":"CSB-PA889082LC01HU","price":484.78,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_9431a2e0-893d-4ff1-b5db-d1f47d4baa9c.jpg?v=1660146308","url":"https:\/\/www.genebiosystems.com\/products\/kmt5a-antibody-fitc-conjugated-cat-csb-pa889082lc01hu","provider":"GeneBio ","version":"1.0","type":"link"}