{"product_id":"invivomab-anti-rat-cd198-ccr8-antibody-iv0256","title":"InVivoMAb Anti-Rat CD198\/CCR8 Antibody (Iv0256)","description":"\u003cp\u003e\u003cb\u003eSize\u003c\/b\u003e:100ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eDescription\u003c\/b\u003e:CCR8, a receptor selectively expressed on activated Tregs within tumors, plays a key role in maintaining local immunosuppression. Iv0256 is a rat-reactive CCR8 antibody with improved functional potency. In CD34 humanized mice, Iv0256 markedly reduced HCC827 lung tumor growth after intravenous administration. In syngeneic LLC and H22 models, intraperitoneal Iv0256 also achieved robust tumor suppression, displaying a pronounced dose-response pattern across tested doses.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eHost species\u003c\/b\u003e:Mouse\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies reactivity\u003c\/b\u003e:Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStorage buffer\u003c\/b\u003e:0.01M PBS, pH 7.4.\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurity\u003c\/b\u003e:\u0026gt;95% as determined by SDS-PAGE.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Monoclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG2a, kappa\u003c\/p\u003e\u003cp\u003e\u003cb\u003eApplications\u003c\/b\u003e:ELISA, Neutralization\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget\u003c\/b\u003e:C-C motif chemokine receptor 8, Ccr8\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification\u003c\/b\u003e:Protein A\/G purified from cell culture supernatant.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eEndotoxin level\u003c\/b\u003e:Please contact us for this information.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAccession\u003c\/b\u003e:D4ADE0\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStability and Storage\u003c\/b\u003e:Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at -20°C 12 months. Store at -80°C long term.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone ID\u003c\/b\u003e:Iv0256\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Usage Information\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePredicted molecular weight\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eNote\u003c\/b\u003e:For research use only. Not suitable for clinical or therapeutic use.\u003c\/p\u003e","brand":"GeneBio Systems","offers":[{"title":"Default Title","offer_id":48672853622884,"sku":"RW444010","price":777.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/files\/no_image_default_image-jpeg_497ea545-4ded-4de4-b12f-3865577a62c0.jpg?v=1782937150","url":"https:\/\/www.genebiosystems.com\/products\/invivomab-anti-rat-cd198-ccr8-antibody-iv0256","provider":"GeneBio ","version":"1.0","type":"link"}