{"product_id":"erbb2-antibody-cat-csb-pa007763ka01hu","title":"ERBB2 Antibody - Cat. #: CSB-PA007763KA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro\/glioblastoma derived oncogene homolog antibody; C erb B2\/neu protein antibody; CD340 antibody; CD340 antigen antibody; Cerb B2\/neu protein antibody; CerbB2 antibody; Erb b2 receptor tyrosine kinase 2 antibody; ErbB-2 proto-oncogene antibody; ERBB2 antibody; ERBB2_HUMAN antibody; HER 2 antibody; HER 2\/NEU antibody; HER2 antibody; Herstatin antibody; Human epidermal growth factor receptor 2 antibody; Metastatic lymph node gene 19 protein antibody; MLN 19 antibody; MLN19 antibody; NEU antibody; NEU proto oncogene antibody; Neuro\/glioblastoma derived oncogene homolog antibody; Neuroblastoma\/glioblastoma derived oncogene homolog antibody; NGL antibody; p185erbB2 antibody; Proto-oncogene c-ErbB-2 antibody; Proto-oncogene Neu antibody; Receptor tyrosine-protein kinase erbB-2 antibody; TKR1 antibody; Tyrosine kinase type cell surface receptor HER2 antibody; Tyrosine kinase-type cell surface receptor HER2 antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 (neuro\/glioblastoma derived oncogene homolog) antibody; V erb b2 avian erythroblastic leukemia viral oncogene homolog 2 antibody; V erb b2 avian erythroblastic leukemia viral oncoprotein 2 antibody; V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro\/glioblastoma derived oncogene homolog (avian) antibody; V erb b2 erythroblastic leukemia viral oncogene homolog 2, neuro\/glioblastoma derived oncogene homolog antibody; Verb b2 erythroblastic leukemia viral oncogene homolog 2, neuro\/glioblastoma derived oncogene homolog (avian) antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P04626\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:A synthetic peptide of Human ERBB2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human, Mouse, Rat\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; WB:1:500-1:1000, IHC:1:50-1:100\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 (homologous to Tyr416 of pp60c-Src) may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221\/1222; phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Affinity purification\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Store at -20°C or -80°C. Avoid freeze \/ thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:ERBB2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Cancer;Tags \u0026amp; Cell Markers?Immunology;Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483676029028,"sku":"CSB-PA007763KA01HU","price":1162.28,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_a52e9dfa-ab68-4b52-bc38-e1c97ab824ce.jpg?v=1660073613","url":"https:\/\/www.genebiosystems.com\/products\/erbb2-antibody-cat-csb-pa007763ka01hu","provider":"GeneBio ","version":"1.0","type":"link"}