{"product_id":"adra2b-antibody-cat-csb-pa585658","title":"ADRA2B Antibody - Cat. #: CSB-PA585658","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:100ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:ADRA2B antibody; ADRA2L1 antibody; ADRA2RL1Alpha-2B adrenergic receptor antibody; Alpha-2 adrenergic receptor subtype C2 antibody; Alpha-2B adrenoreceptor antibody; Alpha-2B adrenoceptor antibody; Alpha-2BAR antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:P18089\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Synthesized peptide derived from internal of Human Adrenergic Receptor alpha-2B.\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, IF; IF:1:100-1:500\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The rank order of potency for agonists of this receptor is clonidine \u0026gt; norepinephrine \u0026gt; epinephrine = oxymetazoline \u0026gt; dopamine \u0026gt; p-tyramine = phenylephrine \u0026gt; serotonin \u0026gt; p-synephrine \/ p-octopamine. For antagonists, the rank order is yohimbine \u0026gt; chlorpromazine \u0026gt; phentolamine \u0026gt; mianserine \u0026gt; spiperone \u0026gt; prazosin \u0026gt; alprenolol \u0026gt; propanolol \u0026gt; pindolol.\u003cbr\u003e\u003cbr\u003eLomasney J.W., Proc. Natl. Acad. Sci. U.S.A. 87:5094-5098(1990).\u003cbr\u003eWeinshank R.L., Mol. Pharmacol. 38:681-688(1990).\u003cbr\u003eSmall K.M., J. Biol. Chem. 276:4917-4922(2001).\u003cbr\u003e\n\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:ADRA2B\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Signal transduction\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40483704799332,"sku":"CSB-PA585658","price":867.34,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_9fa12ce7-9021-4d4a-b75b-f389a1728a9d.jpg?v=1660074248","url":"https:\/\/www.genebiosystems.com\/products\/adra2b-antibody-cat-csb-pa585658","provider":"GeneBio ","version":"1.0","type":"link"}