{"product_id":"trim33-antibody-cat-csb-pa891796la01hu","title":"TRIM33 Antibody - Cat. #: CSB-PA891796LA01HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ug\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:8030451N04Rik antibody; AI413936 antibody; cb1085 antibody; DKFZp586K1123 antibody; E3 ubiquitin-protein ligase TRIM33 antibody; EC 6.3.2.- antibody; Ectodermin antibody; Ectodermin homolog antibody; FLJ11429 antibody; FLJ32925 antibody; id:ibd2175 antibody; MGC136680 antibody; mKIAA1113 antibody; OTTHUMP00000013662 antibody; OTTHUMP00000013663 antibody; Protein Rfg7 antibody; PTC7 antibody; Ret fused gene 7 antibody; RET-fused gene 7 protein antibody; RFG7 antibody; Rfg7 protein antibody; TF1G antibody; TIF1 gamma antibody; TIF1-gamma antibody; TIF1G antibody; TIF1GAMMA antibody; TIFGAMMA antibody; Transcription intermediary factor 1-gamma antibody; Transcriptional intermediary factor 1 gamma antibody; TRI33_HUMAN antibody; trim33 antibody; Tripartite motif containing 33 antibody; Tripartite motif containing 33 protein antibody; tripartite motif-containing 33 antibody; Tripartite motif-containing protein 33 antibody; wu:fc17f10 antibody; zgc:136680 antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q9UPN9\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human E3 ubiquitin-protein ligase TRIM33 protein (1-273AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, IHC, IF; Recommended dilution: IHC:1:20-1:200, IF:1:50-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Acts as an E3 ubiquitin-protein ligase. Promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. According to PubMed:16751102, does not promote a decrease in the level of endogenous SMAD4. May act as a transcriptional repressor. Inhibits the transcriptional response to TGF-beta\/BMP signaling cascade. Plays a role in the control of cell proliferation. Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem\/progenitor (By similarity). Monoubiquitinates SMAD4 and acts as an inhibitor of SMAD4-dependent TGF-beta\/BMP signaling cascade (Monoubiquitination of SMAD4 hampers its ability to form a stable complex with activated SMAD2\/3 resulting in inhibition of TGF-beta\/BMP signaling cascade).\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:\u0026gt;95%, Protein G purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:Preservative: 0.03% Proclin 300\u003cbr\u003eConstituents: 50% Glycerol, 0.01M PBS, pH 7.4\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:TRIM33\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling; Stem cells\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486756483172,"sku":"CSB-PA891796LA01HU","price":408.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_8c9a6df4-a616-4491-9217-810d33b2699a.jpg?v=1660152634","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/trim33-antibody-cat-csb-pa891796la01hu","provider":"GeneBio ","version":"1.0","type":"link"}