{"product_id":"suv39h2-antibody-cat-csb-pa872500esr2hu","title":"SUV39H2 Antibody - Cat. #: CSB-PA872500ESR2HU","description":"\u003cp\u003e\u003cb\u003eSize \u003c\/b\u003e:50ul\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClone Number\u003c\/b\u003e:\u003c\/p\u003e\u003cp\u003e\u003cb\u003eAliases\u003c\/b\u003e:FLJ23414 antibody; H3 K9 HMTase 2 antibody; H3-K9-HMTase 2 antibody; Histone H3 K9 methyltransferase 2 antibody; Histone H3-K9 methyltransferase 2 antibody; Histone lysine N methyltransferase H3 lysine 9 specific 2 antibody; Histone lysine N methyltransferase SUV39H2 antibody; Histone-lysine N-methyltransferase SUV39H2 antibody; KMT1B antibody; Lysine N methyltransferase 1B antibody; Lysine N-methyltransferase 1B antibody; sSuppressor of variegation 3 9 homolog 2 (Drosophila) antibody; Su(var)3 9 Drosophila homolog of 2 antibody; Su(var)3 9 homolog 2 antibody; Su(var)3-9 homolog 2 antibody; Suppressor of variegation 3 9 homolog 2 antibody; Suppressor of variegation 3-9 homolog 2 antibody; Suv39h2 antibody; SUV92_HUMAN antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eProduct Type\u003c\/b\u003e:Polyclonal Antibody\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen Species\u003c\/b\u003e:Homo sapiens (Human)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eUniProt ID\u003c\/b\u003e:Q9H5I1\u003c\/p\u003e\u003cp\u003e\u003cb\u003eImmunogen\u003c\/b\u003e:Recombinant Human Histone-lysine N-methyltransferase SUV39H2 protein (201-410AA)\u003c\/p\u003e\u003cp\u003e\u003cb\u003eRaised in\u003c\/b\u003e:Rabbit\u003c\/p\u003e\u003cp\u003e\u003cb\u003eSpecies Reactivity\u003c\/b\u003e:Human\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTested Applications\u003c\/b\u003e:ELISA, WB, IHC; Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBackground\u003c\/b\u003e:Histone methyltransferase that specifically trimethylates \\\\\\'Lys-9\\\\\\' of histone H3 using monomethylated H3 \\\\\\'Lys-9\\\\\\' as substrate. H3 \\\\\\'Lys-9\\\\\\' trimethylation represents a specific tag for epigenetic transcriptional repression by recruiting HP1 (CBX1, CBX3 and\/or CBX5) proteins to methylated histones. Mainly functions in heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin at pericentric and telomere regions. H3 \\\\\\'Lys-9\\\\\\' trimethylation is also required to direct DNA methylation at pericentric repeats. SUV39H1 is targeted to histone H3 via its interaction with RB1 and is involved in many processes, such as cell cycle regulation, transcriptional repression and regulation of telomere length. May participate in regulation of higher-order chromatin organization during spermatogenesis. Recruited by the large PER complex to the E-box elements of the circadian target genes such as PER2 itself or PER1, contributes to the conversion of local chromatin to a heterochromatin-like repressive state through H3 \\\\\\'Lys-9\\\\\\' trimethylation.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eClonality\u003c\/b\u003e:Polyclonal\u003c\/p\u003e\u003cp\u003e\u003cb\u003eIsotype\u003c\/b\u003e:IgG\u003c\/p\u003e\u003cp\u003e\u003cb\u003ePurification Method\u003c\/b\u003e:Antigen Affinity Purified\u003c\/p\u003e\u003cp\u003e\u003cb\u003eConjugate\u003c\/b\u003e:Non-conjugated\u003c\/p\u003e\u003cp\u003e\u003cb\u003eBuffer\u003c\/b\u003e:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eForm\u003c\/b\u003e:Liquid\u003c\/p\u003e\u003cp\u003e\u003cb\u003eStroage\u003c\/b\u003e:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.\u003c\/p\u003e\u003cp\u003e\u003cb\u003eTarget Names\u003c\/b\u003e:SUV39H2\u003c\/p\u003e\u003cp\u003e\u003cb\u003eResearch Areas\u003c\/b\u003e:Epigenetics and Nuclear Signaling\u003c\/p\u003e","brand":"Gene Bio Systems","offers":[{"title":"Default Title","offer_id":40486033817700,"sku":"CSB-PA872500ESR2HU","price":409.0,"currency_code":"USD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0558\/8588\/9636\/products\/no_image_default_image-jpeg_ea0615a2-d992-4e19-a9e3-0850bacfa79a.jpg?v=1660139830","url":"https:\/\/www.genebiosystems.com\/en-us\/products\/suv39h2-antibody-cat-csb-pa872500esr2hu","provider":"GeneBio ","version":"1.0","type":"link"}